InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: HSF2

Summary

InnateDB Protein

IDBP-95989.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

HSF2

Protein Name

heat shock transcription factor 2

Synonyms

HSF 2; HSTF 2;

Species

Homo sapiens

Ensembl Protein

ENSP00000357440

InnateDB Gene

IDBG-95987 (HSF2)

Protein Structure

UniProt Annotation

Function

DNA-binding protein that specifically binds heat shock promoter elements (HSE) and activates transcription. In higher eukaryotes, HSF is unable to bind to the HSE unless the cells are heat shocked.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:8339932}. Nucleus {ECO:0000269PubMed:8339932}. Note=Cytoplasmic during normal growth and moves to the nucleus upon activation.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 51 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	51 [view]
Protein-Protein	50 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001162	RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003713	transcription coactivator activity
GO:0042803	protein homodimerization activity
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0006355	regulation of transcription, DNA-templated
GO:0006366	transcription from RNA polymerase II promoter
GO:0006950	response to stress
GO:0007283	spermatogenesis
GO:0045944	positive regulation of transcription from RNA polymerase II promoter