Version 5.4
Homo sapiens Gene: TRDN
Summary
InnateDB Gene IDBG-96065.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TRDN
Gene Name triadin
Synonyms CPVT5; TDN; TRISK
Species Homo sapiens
Ensembl Gene ENSG00000186439
Encoded Proteins
IDBP-96067
triadin
IDBP-96069
triadin
IDBP-96073
triadin
IDBP-386610
triadin
IDBP-595851
triadin
IDBP-589769
triadin
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes an integral membrane protein that contains a single transmembrane domain. As similar protein in rabbits plays a role in skeletal muscle excitation-contraction coupling as part of the calcium release complex in association with the ryanodine receptor. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and single nucleotide polymorphisms in this gene may be markers for IgA nephritis. [provided by RefSeq, Oct 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:123216339-123637093
Strand Reverse strand
Band q22.31
Transcripts
ENST00000334268 ENSP00000333984
ENST00000361029 ENSP00000354307
ENST00000359698 ENSP00000352728
ENST00000422596 ENSP00000406768
ENST00000546248 ENSP00000439281
ENST00000542443 ENSP00000437684
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005102 receptor binding
GO:0005515 protein binding
GO:0030674 protein binding, bridging
GO:0042803 protein homodimerization activity
GO:0044325 ion channel binding
Biological Process
GO:0006874 cellular calcium ion homeostasis
GO:0006936 muscle contraction
GO:0010649 regulation of cell communication by electrical coupling
GO:0010880 regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
GO:0014070 response to organic cyclic compound
GO:0014808 release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
GO:0014902 myotube differentiation
GO:0031122 cytoplasmic microtubule organization
GO:0034220 ion transmembrane transport
GO:0051279 regulation of release of sequestered calcium ion into cytosol
GO:0051280 negative regulation of release of sequestered calcium ion into cytosol
GO:0051281 positive regulation of release of sequestered calcium ion into cytosol
GO:0055085 transmembrane transport
GO:0060047 heart contraction
GO:0060315 negative regulation of ryanodine-sensitive calcium-release channel activity
GO:0060316 positive regulation of ryanodine-sensitive calcium-release channel activity
GO:0086036 regulation of cardiac muscle cell membrane potential
GO:0090158 endoplasmic reticulum membrane organization
GO:1901846 positive regulation of cell communication by electrical coupling involved in cardiac conduction
Cellular Component
GO:0005737 cytoplasm
GO:0005783 endoplasmic reticulum
GO:0005886 plasma membrane
GO:0005891 voltage-gated calcium channel complex
GO:0014701 junctional sarcoplasmic reticulum membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0016529 sarcoplasmic reticulum
GO:0030314 junctional membrane complex
GO:0033017 sarcoplasmic reticulum membrane
GO:0033018 sarcoplasmic reticulum lumen
GO:0034704 calcium channel complex
GO:0043231 intracellular membrane-bounded organelle
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000019787
View Gene Order
ENSBTAG00000038849
Not yet available
Pathways
NETPATH
REACTOME
REACT_160189
Stimuli-sensing channels pathway
REACT_15518
Transmembrane transport of small molecules pathway
REACT_25300
Ion channel transport pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt Q13061
TrEMBL H9ME53 Q5SWK9
UniProt Splice Variant
Entrez Gene 10345
UniGene Hs.144744 Hs.720730
RefSeq NM_001256020 NM_001256021 NM_001256022 NM_006073 XM_006715301 XM_006715302
HUGO HGNC:12261
OMIM 603283
CCDS CCDS59035 CCDS75511
HPRD
IMGT
EMBL AL133257 AL357352 AL445259 AL603902 AL603911 BC070290 BC139910 JN900469 U18985
GenPept AAA75315 AAH70290 AAI39911 AEW10557
RNA Seq Atlas 10345

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca