InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: LAMA2

Summary

InnateDB Gene

IDBG-96327.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

LAMA2

Gene Name

laminin, alpha 2

Synonyms

LAMM

Species

Homo sapiens

Ensembl Gene

ENSG00000196569

Encoded Proteins

IDBP-386912

laminin, alpha 2

IDBP-810998

laminin, alpha 2

IDBP-810999

laminin, alpha 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

Laminin, an extracellular protein, is a major component of the basement membrane. It is thought to mediate the attachment, migration, and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. It is composed of three subunits, alpha, beta, and gamma, which are bound to each other by disulfide bonds into a cross-shaped molecule. This gene encodes the alpha 2 chain, which constitutes one of the subunits of laminin 2 (merosin) and laminin 4 (s-merosin). Mutations in this gene have been identified as the cause of congenital merosin-deficient muscular dystrophy. Two transcript variants encoding different proteins have been found for this gene. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 6:128883141-129516569

Strand

Forward strand

Band

q22.33

Transcripts

ENST00000421865	ENSP00000400365
ENST00000466230
ENST00000498257
ENST00000494137
ENST00000618192	ENSP00000480802
ENST00000617695	ENSP00000481744

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005102	receptor binding
GO:0005198	structural molecule activity
GO:0005515	protein binding

Biological Process

GO:0007155	cell adhesion
GO:0007411	axon guidance
GO:0007517	muscle organ development
GO:0016192	vesicle-mediated transport
GO:0022011	myelination in peripheral nervous system
GO:0030155	regulation of cell adhesion
GO:0030198	extracellular matrix organization
GO:0030334	regulation of cell migration
GO:0032224	positive regulation of synaptic transmission, cholinergic
GO:0045995	regulation of embryonic development

Cellular Component

GO:0005576	extracellular region
GO:0005604	basement membrane
GO:0005605	basal lamina
GO:0005606	laminin-1 complex
GO:0016020	membrane
GO:0031012	extracellular matrix
GO:0042383	sarcolemma
GO:0043197	dendritic spine
GO:0070062	extracellular vesicular exosome

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000019899

View Gene Order

ENSBTAG00000010229

Not yet available

Pathways

NETPATH

NetPath_1

Alpha6Beta4Integrin pathway

REACTOME

REACT_118779

Extracellular matrix organization pathway

REACT_163906

ECM proteoglycans pathway

REACT_163874

Non-integrin membrane-ECM interactions pathway

REACT_169262

Laminin interactions pathway

KEGG

hsa04512

ECM-receptor interaction pathway

hsa05222

Small cell lung cancer pathway

hsa04510

Focal adhesion pathway

hsa05412

Arrhythmogenic right ventricular cardiomyopathy (ARVC) pathway

hsa05410

Hypertrophic cardiomyopathy (HCM) pathway

hsa05200

Pathways in cancer pathway

hsa05414

Dilated cardiomyopathy pathway

hsa05416

Viral myocarditis pathway

hsa05146

Amoebiasis pathway

hsa05145

Toxoplasmosis pathway

INOH

PID NCI

integrin1_pathway

Beta1 integrin cell surface interactions

integrin4_pathway

Alpha6 beta4 integrin-ligand interactions

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.200841

RefSeq

NM_000426 NM_001079823

HUGO

OMIM

CCDS

CCDS5138

HPRD

01125

IMGT

EMBL

GenPept

RNA Seq Atlas