Version 5.4
Homo sapiens Gene: ARG1
Summary
InnateDB Gene IDBG-96496.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ARG1
Gene Name arginase, liver
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000118520
Encoded Proteins
IDBP-96498
arginase, liver
IDBP-96500
arginase, liver
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 18978793
ARG1 expression induced by intracellular pathogens in mouse classically activated macrophages (CAMs) through the TLR pathway, suppressing nitric oxide production and thwarting effective immunity independent of the STAT6 pathway.
PMID 25015834
PI3K/PTEN-regulated extracellular ARG1 acts as a paracrine regulator of inflammation and immunity. Demonstrated in mice.
Entrez Gene
Summary Arginase catalyzes the hydrolysis of arginine to ornithine and urea. At least two isoforms of mammalian arginase exist (types I and II) which differ in their tissue distribution, subcellular localization, immunologic crossreactivity and physiologic function. The type I isoform encoded by this gene, is a cytosolic enzyme and expressed predominantly in the liver as a component of the urea cycle. Inherited deficiency of this enzyme results in argininemia, an autosomal recessive disorder characterized by hyperammonemia. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:131573144-131584332
Strand Forward strand
Band q23.2
Transcripts
ENST00000368087 ENSP00000357066
ENST00000356962 ENSP00000349446
ENST00000275196
ENST00000469293
ENST00000498260
ENST00000484820
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 26 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated
Total 26 [view]
Protein-Protein 26 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004053 arginase activity
GO:0030145 manganese ion binding
GO:0046872 metal ion binding
Biological Process
GO:0000050 urea cycle
GO:0001889 liver development
GO:0001938 positive regulation of endothelial cell proliferation
GO:0006525 arginine metabolic process
GO:0006527 arginine catabolic process
GO:0007565 female pregnancy
GO:0009611 response to wounding
GO:0009635 response to herbicide
GO:0010042 response to manganese ion
GO:0010043 response to zinc ion
GO:0010269 response to selenium ion
GO:0010963 regulation of L-arginine import
GO:0014075 response to amine
GO:0030324 lung development
GO:0032496 response to lipopolysaccharide
GO:0032964 collagen biosynthetic process
GO:0033189 response to vitamin A
GO:0033197 response to vitamin E
GO:0034641 cellular nitrogen compound metabolic process
GO:0042493 response to drug
GO:0043200 response to amino acid
GO:0043434 response to peptide hormone
GO:0044281 small molecule metabolic process
GO:0045087 innate immune response (InnateDB)
GO:0046686 response to cadmium ion
GO:0048545 response to steroid hormone
GO:0048678 response to axon injury
GO:0051597 response to methylmercury
GO:0060056 mammary gland involution
GO:0060135 maternal process involved in female pregnancy
GO:0070207 protein homotrimerization
GO:0070301 cellular response to hydrogen peroxide
GO:0071222 cellular response to lipopolysaccharide
GO:0071353 cellular response to interleukin-4
GO:0071377 cellular response to glucagon stimulus
GO:0071549 cellular response to dexamethasone stimulus
GO:0071560 cellular response to transforming growth factor beta stimulus
Cellular Component
GO:0005615 extracellular space
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0043005 neuron projection
GO:0043025 neuronal cell body
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000019987
View Gene Order
ENSBTAG00000012403
Not yet available
Pathways
NETPATH
REACTOME
REACT_847
Urea cycle pathway
REACT_13
Metabolism of amino acids and derivatives pathway
REACT_111217
Metabolism pathway
KEGG
hsa00330
Arginine and proline metabolism pathway
hsa05146
Amoebiasis pathway
INOH
INOH website
Arginine Proline metabolism pathway
PID NCI
atf2_pathway
ATF-2 transcription factor network
il4_2pathway
IL4-mediated signaling events
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_000045 NM_001244438
HUGO
OMIM
CCDS CCDS5145 CCDS59038
HPRD 01947
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca