InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ARG1

Summary

InnateDB Protein

IDBP-96498.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ARG1

Protein Name

arginase, liver

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000357066

InnateDB Gene

IDBG-96496 (ARG1)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:16141327}.

Disease Associations

Argininemia (ARGIN) [MIM:207800]: A rare autosomal recessive disorder of the urea cycle. Arginine is elevated in the blood and cerebrospinal fluid, and periodic hyperammonemia occurs. Clinical manifestations include developmental delay, seizures, mental retardation, hypotonia, ataxia and progressive spastic quadriplegia. {ECO:0000269PubMed:1463019, ECO:0000269PubMed:7649538}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 26 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	26 [view]
Protein-Protein	26 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004053	arginase activity
GO:0046872	metal ion binding

Biological Process

GO:0000050	urea cycle
GO:0006525	arginine metabolic process
GO:0006527	arginine catabolic process
GO:0034641	cellular nitrogen compound metabolic process
GO:0044281	small molecule metabolic process
GO:0045087	innate immune response (InnateDB)