Version 5.4
Homo sapiens Gene: VNN2
Summary
InnateDB Gene IDBG-96680.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol VNN2
Gene Name vanin 2
Synonyms FOAP-4; GPI-80
Species Homo sapiens
Ensembl Gene ENSG00000112303
Encoded Proteins
IDBP-96684
vanin 2
IDBP-245756
vanin 2
IDBP-387196
vanin 2
IDBP-387198
vanin 2
IDBP-588900
vanin 2
IDBP-601136
vanin 2
IDBP-591888
vanin 2
IDBP-591426
vanin 2
IDBP-603221
vanin 2
IDBP-587540
vanin 2
IDBP-600642
vanin 2
IDBP-600058
vanin 2
IDBP-585930
vanin 2
IDBP-592029
vanin 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene product is a member of the Vanin family of proteins that share extensive sequence similarity with each other, and also with biotinidase. The family includes secreted and membrane-associated proteins, a few of which have been reported to participate in hematopoietic cell trafficking. No biotinidase activity has been demonstrated for any of the vanin proteins, however, they possess pantetheinase activity, which may play a role in oxidative-stress response. The encoded protein is a GPI-anchored cell surface molecule that plays a role in transendothelial migration of neutrophils. This gene lies in close proximity to, and in same transcriptional orientation as two other vanin genes on chromosome 6q23-q24. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, May 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:132743870-132763459
Strand Reverse strand
Band q23.2
Transcripts
ENST00000326499 ENSP00000322276
ENST00000392389 ENSP00000376190
ENST00000418593 ENSP00000387572
ENST00000422400 ENSP00000406536
ENST00000525270 ENSP00000436822
ENST00000525674 ENSP00000436863
ENST00000525289 ENSP00000436935
ENST00000532053 ENSP00000434077
ENST00000528801 ENSP00000433285
ENST00000533835 ENSP00000432516
ENST00000531279 ENSP00000432582
ENST00000526157
ENST00000526192
ENST00000524919 ENSP00000431451
ENST00000530536 ENSP00000434210
ENST00000532012 ENSP00000431680
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
GO:0017159 pantetheine hydrolase activity
Biological Process
GO:0006807 nitrogen compound metabolic process
GO:0006928 cellular component movement
GO:0015939 pantothenate metabolic process
Cellular Component
GO:0005886 plasma membrane
GO:0031225 anchored component of membrane
Orthologs
No orthologs found for this gene
Pathways
NETPATH
REACTOME
KEGG
hsa00770
Pantothenate and CoA biosynthesis pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL E9PRD9
UniProt Splice Variant
Entrez Gene 8875
UniGene Hs.293130
RefSeq NM_001242350 NM_004665 NM_078488 XM_006715593
HUGO HGNC:12706
OMIM 603571
CCDS CCDS5161 CCDS5162 CCDS56451
HPRD 04652
IMGT
EMBL AL032821
GenPept
RNA Seq Atlas 8875

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca