Version 5.4
Homo sapiens Protein: VNN2
Summary
InnateDB Protein IDBP-96684.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol VNN2
Protein Name vanin 2
Synonyms FOAP-4; GPI-80;
Species Homo sapiens
Ensembl Protein ENSP00000322276
InnateDB Gene IDBG-96680 (VNN2)
Protein Structure
UniProt Annotation
Function Amidohydrolase that hydrolyzes specifically one of the carboamide linkages in D-pantetheine thus recycling pantothenic acid (vitamin B5) and releasing cysteamine. Involved in the thymus homing of bone marrow cells. May regulate beta-2 integrin-mediated cell adhesion, migration and motility of neutrophil. {ECO:0000269PubMed:11491533}.
Subcellular Localization Cell membrane {ECO:0000305}; Lipid-anchor, GPI-anchor {ECO:0000305}.
Disease Associations
Tissue Specificity Widely expressed with higher expression in spleen and blood. {ECO:0000269PubMed:19322213}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
GO:0017159 pantetheine hydrolase activity
Biological Process
GO:0006807 nitrogen compound metabolic process
GO:0006928 cellular component movement
GO:0015939 pantothenate metabolic process
Cellular Component
GO:0005886 plasma membrane
GO:0031225 anchored component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR003010 Carbon-nitrogen hydrolase
IPR012101 Biotinidase, eukaryotic
PFAM PF00795
PRINTS
PIRSF PIRSF011861
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O95498
PhosphoSite PhosphoSite-O95498
TrEMBL E9PRD9
UniProt Splice Variant
Entrez Gene 8875
UniGene Hs.293130
RefSeq NP_004656
HUGO HGNC:12706
OMIM 603571
CCDS CCDS5161
HPRD 04652
IMGT
EMBL AB026705 AB435062 AB435063 AB435064 AB435065 AJ132100 AK290908 AK292125 AL032821 BC126145 BC126147 CH471051 D89974 DQ249347
GenPept AAI26146 AAI26148 ABB72673 BAA82525 BAB61019 BAF83597 BAF84814 BAG30934 BAG30935 BAG30936 BAG30937 CAA10569 CAB40076 EAW48016

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca