InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: MAP3K5

Summary

InnateDB Gene

IDBG-96934.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MAP3K5

Gene Name

mitogen-activated protein kinase kinase kinase 5

Synonyms

ASK1; MAPKKK5; MEKK5

Species

Homo sapiens

Ensembl Gene

ENSG00000197442

Encoded Proteins

IDBP-96938

mitogen-activated protein kinase kinase kinase 5

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 21515258

MAP3K5 is required for LPS-induced activation of p38, which is a crucial determinant of the production of pro-inflammatory cytokines in endotoxemia. (Demonstrated in murine model)

InnateDB Annotation from Orthologs

Summary

PMID 21515258

[Mus musculus] Map3k5 is required for LPS-induced activation of p38, which is a crucial determinant of the production of pro-inflammatory cytokines in endotoxemia.

Entrez Gene

Summary

Mitogen-activated protein kinase (MAPK) signaling cascades include MAPK or extracellular signal-regulated kinase (ERK), MAPK kinase (MKK or MEK), and MAPK kinase kinase (MAPKKK or MEKK). MAPKK kinase/MEKK phosphorylates and activates its downstream protein kinase, MAPK kinase/MEK, which in turn activates MAPK. The kinases of these signaling cascades are highly conserved, and homologs exist in yeast, Drosophila, and mammalian cells. MAPKKK5 contains 1,374 amino acids with all 11 kinase subdomains. Northern blot analysis shows that MAPKKK5 transcript is abundantly expressed in human heart and pancreas. The MAPKKK5 protein phosphorylates and activates MKK4 (aliases SERK1, MAPKK4) in vitro, and activates c-Jun N-terminal kinase (JNK)/stress-activated protein kinase (SAPK) during transient expression in COS and 293 cells; MAPKKK5 does not activate MAPK/ERK. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 6:136557047-136792518

Strand

Reverse strand

Band

q23.3

Transcripts

ENST00000359015	ENSP00000351908
ENST00000463140

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 137 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.

Experimentally validated
Total	137 [view]
Protein-Protein	132 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	2 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	11 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000287	magnesium ion binding
GO:0004672	protein kinase activity
GO:0004709	MAP kinase kinase kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008656	cysteine-type endopeptidase activator activity involved in apoptotic process
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0019901	protein kinase binding
GO:0019903	protein phosphatase binding
GO:0042803	protein homodimerization activity

Biological Process

GO:0000165	MAPK cascade
GO:0000186	activation of MAPKK activity
GO:0000187	activation of MAPK activity
GO:0001934	positive regulation of protein phosphorylation
GO:0002931	response to ischemia
GO:0006468	protein phosphorylation
GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0007254	JNK cascade
GO:0007257	activation of JUN kinase activity
GO:0008631	intrinsic apoptotic signaling pathway in response to oxidative stress
GO:0010941	regulation of cell death
GO:0016032	viral process
GO:0043065	positive regulation of apoptotic process
GO:0043280	positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0045087	innate immune response (InnateDB)
GO:0070301	cellular response to hydrogen peroxide
GO:0097190	apoptotic signaling pathway
GO:0097300	programmed necrotic cell death
GO:1901216	positive regulation of neuron death
GO:1902170	cellular response to reactive nitrogen species