Version 5.4
Homo sapiens Gene: IL20RA
Summary
InnateDB Gene IDBG-96985.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol IL20RA
Gene Name interleukin 20 receptor, alpha
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000016402
Encoded Proteins
IDBP-96987
interleukin 20 receptor, alpha
IDBP-96989
interleukin 20 receptor, alpha
IDBP-96991
interleukin 20 receptor, alpha
IDBP-593392
interleukin 20 receptor, alpha
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
PMID 24677051
[Mus musculus] Astrocytes produce IL19 and express IL19 receptors (Il20ra and Il20rb) in response to bacterial pathogens. IL19 can significantly attenuate bacterially induced inflammatory astrocyte responses
Entrez Gene
Summary The protein encoded by this gene is a receptor for interleukin 20 (IL20), a cytokine that may be involved in epidermal function. The receptor of IL20 is a heterodimeric receptor complex consisting of this protein and interleukin 20 receptor beta (IL20B). This gene and IL20B are highly expressed in skin. The expression of both genes is found to be upregulated in Psoriasis. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:136999971-137045180
Strand Reverse strand
Band q23.3
Transcripts
ENST00000316649 ENSP00000314976
ENST00000367748 ENSP00000356722
ENST00000367746 ENSP00000356720
ENST00000468393
ENST00000461799
ENST00000460306
ENST00000541547 ENSP00000437843
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0042015 interleukin-20 binding
Biological Process
GO:0019221 cytokine-mediated signaling pathway
GO:0045124 regulation of bone resorption
GO:2001244 positive regulation of intrinsic apoptotic signaling pathway
Cellular Component
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000020007
View Gene Order
ENSBTAG00000015638
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa04060
Cytokine-cytokine receptor interaction pathway
hsa04630
Jak-STAT signaling pathway pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.445868 Hs.600366 Hs.734385
RefSeq NM_001278722 NM_001278723 NM_001278724 NM_014432
HUGO
OMIM
CCDS CCDS5181 CCDS64535 CCDS64536
HPRD 05729
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca