Version 5.4
Homo sapiens Gene: CASC4
Summary
InnateDB Gene IDBG-9717.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CASC4
Gene Name cancer susceptibility candidate 4
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000166734
Encoded Proteins
IDBP-9719
cancer susceptibility candidate 4
IDBP-9721
cancer susceptibility candidate 4
IDBP-591662
cancer susceptibility candidate 4
IDBP-593514
cancer susceptibility candidate 4
IDBP-589684
cancer susceptibility candidate 4
IDBP-583224
cancer susceptibility candidate 4
IDBP-584533
cancer susceptibility candidate 4
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The increased expression level of this gene is associated with HER-2/neu proto-oncogene overexpression. Amplification and resulting overexpression of this proto-oncogene are found in approximately 30% of human breast and 20% of human ovarian cancers. Alternatively spliced variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Dec 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 15:44288729-44415758
Strand Forward strand
Band q15.3
Transcripts
ENST00000299957 ENSP00000299957
ENST00000345795 ENSP00000335063
ENST00000429162
ENST00000559222 ENSP00000453703
ENST00000557945 ENSP00000453720
ENST00000558735 ENSP00000453850
ENST00000559037
ENST00000558847 ENSP00000453465
ENST00000559550
ENST00000561305 ENSP00000452833
ENST00000559151
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated
Total 4 [view]
Protein-Protein 2 [view]
Protein-DNA 1 [view]
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
Cellular Component
GO:0005794 Golgi apparatus
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000060227
View Gene Order
ENSBTAG00000012545
Not yet available
Cross-References
SwissProt Q6P4E1
TrEMBL A0A024R5S2
UniProt Splice Variant
Entrez Gene 113201
UniGene Hs.512867 Hs.593919 Hs.601422 Hs.679724 Hs.701849
RefSeq NM_138423 NM_177974
HUGO HGNC:24892
OMIM
CCDS CCDS10108 CCDS10109
HPRD 11018
IMGT
EMBL AC025043 AC090519 AK298564 AL832333 AY358086 BC012124 BC063480 CH471082
GenPept AAH12124 AAH63480 AAQ88453 BAG60758 EAW77257 EAW77258 EAW77260
RNA Seq Atlas 113201

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca