InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: KIF2C

Summary

InnateDB Gene

IDBG-97762.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

KIF2C

Gene Name

kinesin family member 2C

Synonyms

CT139; KNSL6; MCAK

Species

Homo sapiens

Ensembl Gene

ENSG00000142945

Encoded Proteins

IDBP-97764

kinesin family member 2C

IDBP-97770

kinesin family member 2C

IDBP-382859

kinesin family member 2C

IDBP-382863

kinesin family member 2C

IDBP-382873

kinesin family member 2C

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene is a member of kinesin-like protein family. Proteins of this family are microtubule-dependent molecular motors that transport organelles within cells and move chromosomes during cell division. This protein is important for anaphase chromosome segregation and may be required to coordinate the onset of sister centromere separation. [provided by RefSeq, Jul 2008]
This gene encodes a kinesin-like protein that functions as a microtubule-dependent molecular motor. The encoded protein can depolymerize microtubules at the plus end, thereby promoting mitotic chromosome segregation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:44739818-44767767

Strand

Forward strand

Band

p34.1

Transcripts

ENST00000372224	ENSP00000361298
ENST00000372217	ENSP00000361291
ENST00000452259	ENSP00000410346
ENST00000455186	ENSP00000395050
ENST00000423289	ENSP00000402172
ENST00000493027
ENST00000480574
ENST00000472235

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 31 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	31 [view]
Protein-Protein	28 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003777	microtubule motor activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008017	microtubule binding
GO:0019237	centromeric DNA binding
GO:0051010	microtubule plus-end binding

Biological Process

GO:0000278	mitotic cell cycle
GO:0007018	microtubule-based movement
GO:0007019	microtubule depolymerization
GO:0007059	chromosome segregation
GO:0007067	mitotic nuclear division
GO:0007596	blood coagulation
GO:0008152	metabolic process
GO:0008283	cell proliferation
GO:0019886	antigen processing and presentation of exogenous peptide antigen via MHC class II
GO:0030951	establishment or maintenance of microtubule cytoskeleton polarity
GO:0051983	regulation of chromosome segregation

Cellular Component

GO:0000775	chromosome, centromeric region
GO:0000776	kinetochore
GO:0000777	condensed chromosome kinetochore
GO:0005634	nucleus
GO:0005829	cytosol
GO:0005871	kinesin complex
GO:0005874	microtubule
GO:0005881	cytoplasmic microtubule
GO:0015630	microtubule cytoskeleton
GO:0016020	membrane
GO:0035371	microtubule plus-end