InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: KIF2C

Summary

InnateDB Protein

IDBP-97770.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

KIF2C

Protein Name

kinesin family member 2C

Synonyms

CT139; KNSL6; MCAK;

Species

Homo sapiens

Ensembl Protein

ENSP00000361291

InnateDB Gene

IDBG-97762 (KIF2C)

Protein Structure

UniProt Annotation

Function

In complex with KIF18B, constitutes the major microtubule plus-end depolymerizing activity in mitotic cells. Regulates the turnover of microtubules at the kinetochore and functions in chromosome segregation during mitosis. {ECO:0000269PubMed:19060894, ECO:0000269PubMed:21820309}.

Subcellular Localization

Cytoplasm, cytoskeleton {ECO:0000250}. Nucleus {ECO:0000250}. Chromosome, centromere. Chromosome, centromere, kinetochore. Note=Associates with the microtubule network at the growing distal tip (the plus-end) of microtubules, probably through interaction with MTUS2/TIP150 and MAPRE1 (By similarity). Association with microtubule plus ends is also mediated by interaction with KIF18B. Centromeric localization requires the presence of BUB1 and SGOL2. {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed at high levels in thymus and testis, at low levels in small intestine, the mucosal lining of colon, and placenta, and at very low levels in spleen and ovary; expression is not detected in prostate, peripheral blood Leukocytes, heart, brain, lung, liver, skeletal muscle, kidney or pancreas. Isoform 2 is testis-specific. {ECO:0000269PubMed:12383881, ECO:0000269PubMed:9434124}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 31 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	31 [view]
Protein-Protein	28 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003777	microtubule motor activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008017	microtubule binding
GO:0019237	centromeric DNA binding
GO:0051010	microtubule plus-end binding

Biological Process

GO:0000278	mitotic cell cycle
GO:0007018	microtubule-based movement
GO:0007019	microtubule depolymerization
GO:0007059	chromosome segregation
GO:0007067	mitotic nuclear division
GO:0007596	blood coagulation
GO:0008152	metabolic process
GO:0008283	cell proliferation
GO:0019886	antigen processing and presentation of exogenous peptide antigen via MHC class II
GO:0030951	establishment or maintenance of microtubule cytoskeleton polarity
GO:0051983	regulation of chromosome segregation

Cellular Component

GO:0000775	chromosome, centromeric region
GO:0000776	kinetochore
GO:0000777	condensed chromosome kinetochore
GO:0005634	nucleus
GO:0005829	cytosol
GO:0005871	kinesin complex
GO:0005874	microtubule
GO:0005881	cytoplasmic microtubule
GO:0015630	microtubule cytoskeleton
GO:0016020	membrane
GO:0035371	microtubule plus-end