Version 5.4
Homo sapiens Gene: MTRF1L
Summary
InnateDB Gene IDBG-98155.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MTRF1L
Gene Name mitochondrial translational release factor 1-like
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000112031
Encoded Proteins
IDBP-98157
mitochondrial translational release factor 1-like
IDBP-98159
mitochondrial translational release factor 1-like
IDBP-98161
mitochondrial translational release factor 1-like
IDBP-387952
mitochondrial translational release factor 1-like
IDBP-387953
mitochondrial translational release factor 1-like
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Mitochondrial DNA encodes 13 proteins that play essential roles in the respiratory chain, while all proteins involved in mitochondrial translation are encoded by nuclear genes that are imported from the cytoplasm. MTRF1L is a nuclear-encoded protein that functions as a releasing factor that recognizes termination codons and releases mitochondrial ribosomes from the synthesized protein (summary by Nozaki et al., 2008 [PubMed 18429816]).[supplied by OMIM, Nov 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:152987362-153002685
Strand Reverse strand
Band q25.2
Transcripts
ENST00000367233 ENSP00000356202
ENST00000367231 ENSP00000356200
ENST00000367230 ENSP00000356199
ENST00000414771 ENSP00000414383
ENST00000448966 ENSP00000415113
ENST00000461949
ENST00000464135
ENST00000485512
ENST00000463251
ENST00000485283
ENST00000482526
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 1 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003747 translation release factor activity
GO:0016149 translation release factor activity, codon specific
Biological Process
GO:0006415 translational termination
Cellular Component
GO:0005737 cytoplasm
GO:0005739 mitochondrion
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000019774
View Gene Order
ENSBTAG00000009275
Not yet available
Pathways
NETPATH
REACTOME
REACT_200751
Organelle biogenesis and maintenance pathway
REACT_267673
Mitochondrial translation pathway
REACT_267602
Mitochondrial translation termination pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.225836 Hs.304818 Hs.621683 Hs.626987 Hs.670858 Hs.708755 Hs.721577
RefSeq NM_001114184 NM_001301047 NM_019041 XM_005267035 XM_005267037
HUGO
OMIM
CCDS CCDS47502 CCDS5243 CCDS75540
HPRD 17613
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca