InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: CYP4A11

Summary

InnateDB Gene

IDBG-98208.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CYP4A11

Gene Name

cytochrome P450, family 4, subfamily A, polypeptide 11

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000187048

Encoded Proteins

IDBP-98210

cytochrome P450, family 4, subfamily A, polypeptide 11

IDBP-98212

cytochrome P450, family 4, subfamily A, polypeptide 11

IDBP-98214

cytochrome P450, family 4, subfamily A, polypeptide 11

IDBP-809548

cytochrome P450, family 4, subfamily A, polypeptide 11

IDBP-809551

cytochrome P450, family 4, subfamily A, polypeptide 11

IDBP-809553

cytochrome P450, family 4, subfamily A, polypeptide 11

IDBP-809555

cytochrome P450, family 4, subfamily A, polypeptide 11

IDBP-809558

cytochrome P450, family 4, subfamily A, polypeptide 11

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and hydroxylates medium-chain fatty acids such as laurate and myristate. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:46929177-46941484

Strand

Reverse strand

Band

p33

Transcripts

ENST00000310638	ENSP00000311095
ENST00000371905	ENSP00000360972
ENST00000371904	ENSP00000360971
ENST00000475477	ENSP00000476854
ENST00000462347	ENSP00000477495
ENST00000474458	ENSP00000476988
ENST00000468629	ENSP00000476619
ENST00000465874	ENSP00000476368
ENST00000496519

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004497	monooxygenase activity
GO:0005506	iron ion binding
GO:0008392	arachidonic acid epoxygenase activity
GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0018685	alkane 1-monooxygenase activity
GO:0020037	heme binding
GO:0050051	leukotriene-B4 20-monooxygenase activity
GO:0052869	arachidonic acid omega-hydroxylase activity

Biological Process

GO:0001676	long-chain fatty acid metabolic process
GO:0003091	renal water homeostasis
GO:0003095	pressure natriuresis
GO:0006631	fatty acid metabolic process
GO:0006691	leukotriene metabolic process
GO:0006805	xenobiotic metabolic process
GO:0019369	arachidonic acid metabolic process
GO:0019373	epoxygenase P450 pathway
GO:0032305	positive regulation of icosanoid secretion
GO:0036101	leukotriene B4 catabolic process
GO:0044255	cellular lipid metabolic process
GO:0044281	small molecule metabolic process
GO:0055078	sodium ion homeostasis
GO:0055114	oxidation-reduction process
GO:0097267	omega-hydroxylase P450 pathway

Cellular Component

GO:0005737	cytoplasm
GO:0005789	endoplasmic reticulum membrane
GO:0016324	apical plasma membrane
GO:0043231	intracellular membrane-bounded organelle
GO:0070062	extracellular vesicular exosome