InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CYP4A11

Summary

InnateDB Protein

IDBP-98210.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CYP4A11

Protein Name

cytochrome P450, family 4, subfamily A, polypeptide 11

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000311095

InnateDB Gene

IDBG-98208 (CYP4A11)

Protein Structure

UniProt Annotation

Function

Catalyzes the omega- and (omega-1)-hydroxylation of various fatty acids such as laurate, myristate and palmitate. Has little activity toward prostaglandins A1 and E1. Oxidizes arachidonic acid to 20-hydroxyeicosatetraenoic acid (20-HETE). {ECO:0000269PubMed:15611369}.

Subcellular Localization

Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.

Disease Associations

Tissue Specificity

Kidney and liver.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005506	iron ion binding
GO:0008392	arachidonic acid epoxygenase activity
GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0018685	alkane 1-monooxygenase activity
GO:0020037	heme binding
GO:0050051	leukotriene-B4 20-monooxygenase activity
GO:0052869	arachidonic acid omega-hydroxylase activity

Biological Process

GO:0001676	long-chain fatty acid metabolic process
GO:0003091	renal water homeostasis
GO:0003095	pressure natriuresis
GO:0006631	fatty acid metabolic process
GO:0006691	leukotriene metabolic process
GO:0006805	xenobiotic metabolic process
GO:0019369	arachidonic acid metabolic process
GO:0019373	epoxygenase P450 pathway
GO:0032305	positive regulation of icosanoid secretion
GO:0036101	leukotriene B4 catabolic process
GO:0044255	cellular lipid metabolic process
GO:0044281	small molecule metabolic process
GO:0055078	sodium ion homeostasis
GO:0055114	oxidation-reduction process
GO:0097267	omega-hydroxylase P450 pathway

Cellular Component

GO:0005737	cytoplasm
GO:0005789	endoplasmic reticulum membrane
GO:0016324	apical plasma membrane
GO:0043231	intracellular membrane-bounded organelle
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR001128 Cytochrome P450
IPR002401 Cytochrome P450, E-class, group I
IPR002402 Cytochrome P450, E-class, group II
IPR002403 Cytochrome P450, E-class, group IV

PFAM

PF00067

PRINTS

PR00385
PR00463
PR00464
PR00465

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q02928