Version 5.4
Homo sapiens Gene: SYNJ2
Summary
InnateDB Gene IDBG-98393.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SYNJ2
Gene Name synaptojanin 2
Synonyms INPP5H
Species Homo sapiens
Ensembl Gene ENSG00000078269
Encoded Proteins
IDBP-98395
synaptojanin 2
IDBP-98397
synaptojanin 2
IDBP-98401
synaptojanin 2
IDBP-98403
synaptojanin 2
IDBP-388085
synaptojanin 2
IDBP-601430
synaptojanin 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The gene is a member of the inositol-polyphosphate 5-phosphatase family. The encoded protein interacts with the ras-related C3 botulinum toxin substrate 1, which causes translocation of the encoded protein to the plasma membrane where it inhibits clathrin-mediated endocytosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:157981887-158099176
Strand Forward strand
Band q25.3
Transcripts
ENST00000355585 ENSP00000347792
ENST00000367122 ENSP00000356089
ENST00000367113 ENSP00000356080
ENST00000367112 ENSP00000356079
ENST00000449320 ENSP00000411202
ENST00000485863 ENSP00000436657
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
Experimentally validated
Total 13 [view]
Protein-Protein 13 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0003676 nucleic acid binding
GO:0003723 RNA binding
GO:0004439 phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity
GO:0005515 protein binding
GO:0042578 phosphoric ester hydrolase activity
Biological Process
GO:0006644 phospholipid metabolic process
GO:0006661 phosphatidylinositol biosynthetic process
GO:0008152 metabolic process
GO:0044281 small molecule metabolic process
GO:0046856 phosphatidylinositol dephosphorylation
Cellular Component
GO:0005829 cytosol
GO:0016020 membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000023805
View Gene Order
ENSBTAG00000000817
Not yet available
Pathways
NETPATH
REACTOME
REACT_121025
Synthesis of PIPs at the plasma membrane pathway
REACT_22258
Metabolism of lipids and lipoproteins pathway
REACT_121175
PI Metabolism pathway
REACT_120870
Phospholipid metabolism pathway
REACT_111217
Metabolism pathway
KEGG
hsa00562
Inositol phosphate metabolism pathway
hsa04070
Phosphatidylinositol signaling system pathway
INOH
INOH website
Inositol phosphate metabolism pathway
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene 8871
UniGene Hs.434494 Hs.616825 Hs.707706
RefSeq NM_001178088 NM_003898 XM_005267197 XM_005267198 XM_005267199 XM_005267200 XM_006715591 XM_006715592
HUGO HGNC:11504
OMIM 609410
CCDS CCDS5254
HPRD 10259
IMGT
EMBL
GenPept
RNA Seq Atlas 8871

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca