InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SYNJ2

Summary

InnateDB Protein

IDBP-98395.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SYNJ2

Protein Name

synaptojanin 2

Synonyms

INPP5H;

Species

Homo sapiens

Ensembl Protein

ENSP00000347792

InnateDB Gene

IDBG-98393 (SYNJ2)

Protein Structure

UniProt Annotation

Function

Inositol 5-phosphatase which may be involved in distinct membrane trafficking and signal transduction pathways. May mediate the inhibitory effect of Rac1 on endocytosis.

Subcellular Localization

Membrane {ECO:0000250}. Note=Predominantly associated with the particulate fractions. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.

Experimentally validated
Total	13 [view]
Protein-Protein	13 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0003676	nucleic acid binding
GO:0003723	RNA binding
GO:0004439	phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity
GO:0005515	protein binding
GO:0042578	phosphoric ester hydrolase activity

Biological Process

GO:0006644	phospholipid metabolic process
GO:0006661	phosphatidylinositol biosynthetic process
GO:0044281	small molecule metabolic process
GO:0046856	phosphatidylinositol dephosphorylation

Cellular Component

GO:0005829	cytosol
GO:0016020	membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000300 Inositol polyphosphate-related phosphatase
IPR000504 RNA recognition motif domain
IPR002013 Synaptojanin, N-terminal
IPR005135 Endonuclease/exonuclease/phosphatase
IPR015047 Domain of unknown function DUF1866

PFAM

PF00076
PF02383
PF03372
PF14529
PF08952

PRINTS

PIRSF

SMART

SM00128
SM00360

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

O15056