Version 5.4
Homo sapiens Gene: IGF2R
Summary
InnateDB Gene IDBG-98588.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol IGF2R
Gene Name insulin-like growth factor 2 receptor
Synonyms CD222; CIMPR; M6P-R; MPR1; MPRI
Species Homo sapiens
Ensembl Gene ENSG00000197081
Encoded Proteins
IDBP-98590
insulin-like growth factor 2 receptor
IDBP-810516
insulin-like growth factor 2 receptor
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a receptor for both, insulin-like growth factor 2 (IGF2) and mannose 6-phosphate (M6P). The IGF2 and M6P binding sites are located on different segments of the receptor. This receptor functions in the intracellular trafficking of lysosomal enzymes, the activation of transforming growth factor beta, and the degradation of IGF2. While the mouse Igf2r gene shows exclusive expression from the maternal allele, imprinting of the human IGF2R gene appears to be polymorphic, with only a minority of individuals showing expression from the maternal allele. [provided by RefSeq, Oct 2010]
This gene encodes a receptor for both insulin-like growth factor 2 and mannose 6-phosphate, although the binding sites for either are located on different segments of the receptor. This receptor functions in the intracellular trafficking of lysosomal enzymes, the activation of transforming growth factor beta, and the degradation of insulin-like growth factor 2. While the related mouse gene shows exclusive expression from the maternal allele, imprinting of the human gene appears to be polymorphic, with only a minority of individuals showing expression from the maternal allele. [provided by RefSeq, Apr 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:159969099-160113507
Strand Forward strand
Band q25.3
Transcripts
ENST00000356956 ENSP00000349437
ENST00000464636
ENST00000487607
ENST00000475834 ENSP00000473880
ENST00000475584
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 33 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 33 [view]
Protein-Protein 30 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001948 glycoprotein binding
GO:0001965 G-protein alpha-subunit binding
GO:0001972 retinoic acid binding
GO:0004872 receptor activity
GO:0004930 G-protein coupled receptor activity
GO:0005010 insulin-like growth factor-activated receptor activity
GO:0005215 transporter activity
GO:0005515 protein binding
GO:0005520 insulin-like growth factor binding
GO:0005537 mannose binding
GO:0019899 enzyme binding
GO:0031995 insulin-like growth factor II binding
GO:0042802 identical protein binding
GO:0051219 phosphoprotein binding
Biological Process
GO:0001889 liver development
GO:0006810 transport
GO:0006898 receptor-mediated endocytosis
GO:0007165 signal transduction
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007283 spermatogenesis
GO:0009791 post-embryonic development
GO:0031100 organ regeneration
GO:0032526 response to retinoic acid
GO:0042981 regulation of apoptotic process
GO:0043065 positive regulation of apoptotic process
GO:0048009 insulin-like growth factor receptor signaling pathway
Cellular Component
GO:0005615 extracellular space
GO:0005634 nucleus
GO:0005641 nuclear envelope lumen
GO:0005737 cytoplasm
GO:0005765 lysosomal membrane
GO:0005768 endosome
GO:0005770 late endosome
GO:0005802 trans-Golgi network
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0009986 cell surface
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0030118 clathrin coat
GO:0030139 endocytic vesicle
GO:0030140 trans-Golgi network transport vesicle
GO:0048471 perinuclear region of cytoplasm
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000023830
View Gene Order
ENSBTAG00000002402
Not yet available
Pathways
NETPATH
REACTOME
REACT_19400
Golgi Associated Vesicle Biogenesis pathway
REACT_19187
Clathrin derived vesicle budding pathway
REACT_11235
trans-Golgi Network Vesicle Budding pathway
REACT_11123
Membrane Trafficking pathway
KEGG
hsa04142
Lysosome pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.487062
RefSeq NM_000876
HUGO
OMIM
CCDS CCDS5273
HPRD 00928
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca