InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: IGF2R

Summary

InnateDB Protein

IDBP-98590.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

IGF2R

Protein Name

insulin-like growth factor 2 receptor

Synonyms

CD222; CIMPR; M6P-R; MPR1; MPRI;

Species

Homo sapiens

Ensembl Protein

ENSP00000349437

InnateDB Gene

IDBG-98588 (IGF2R)

Protein Structure

UniProt Annotation

Function

Transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6- phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelyosomal compartment where the low pH mediates the dissociation of the complex. This receptor also binds IGF2. Acts as a positive regulator of T-cell coactivation, by binding DPP4. {ECO:0000269PubMed:10900005}.

Subcellular Localization

Lysosome membrane {ECO:0000269PubMed:10900005}; Single-pass type I membrane protein {ECO:0000269PubMed:10900005}. Note=Colocalized with DPP4 in internalized cytoplasmic vesicles adjacent to the cell surface.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 33 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	33 [view]
Protein-Protein	30 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001948	glycoprotein binding
GO:0001965	G-protein alpha-subunit binding
GO:0001972	retinoic acid binding
GO:0004872	receptor activity
GO:0004930	G-protein coupled receptor activity
GO:0005010	insulin-like growth factor-activated receptor activity
GO:0005215	transporter activity
GO:0005515	protein binding
GO:0005520	insulin-like growth factor binding
GO:0005537	mannose binding
GO:0019899	enzyme binding
GO:0031995	insulin-like growth factor II binding
GO:0042802	identical protein binding
GO:0051219	phosphoprotein binding

Biological Process

GO:0001889	liver development
GO:0006810	transport
GO:0006898	receptor-mediated endocytosis
GO:0007165	signal transduction
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007283	spermatogenesis
GO:0009791	post-embryonic development
GO:0031100	organ regeneration
GO:0032526	response to retinoic acid
GO:0042981	regulation of apoptotic process
GO:0043065	positive regulation of apoptotic process
GO:0048009	insulin-like growth factor receptor signaling pathway

Cellular Component

GO:0005615	extracellular space
GO:0005634	nucleus
GO:0005641	nuclear envelope lumen
GO:0005737	cytoplasm
GO:0005765	lysosomal membrane
GO:0005768	endosome
GO:0005770	late endosome
GO:0005802	trans-Golgi network
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0009986	cell surface
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0030118	clathrin coat
GO:0030139	endocytic vesicle
GO:0030140	trans-Golgi network transport vesicle
GO:0048471	perinuclear region of cytoplasm
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR000479 Cation-independent mannose-6-phosphate receptor
IPR000562 Fibronectin, type II, collagen-binding
IPR009011 Mannose-6-phosphate receptor binding domain
IPR013806 Kringle-like fold

PFAM

PF00878
PF00040

PRINTS

PIRSF

SMART

SM00059

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P11717