InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: LPA

Summary

InnateDB Gene

IDBG-98731.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

LPA

Gene Name

lipoprotein, Lp(a)

Synonyms

AK38; APOA; LP

Species

Homo sapiens

Ensembl Gene

ENSG00000198670

Encoded Proteins

IDBP-98733

lipoprotein, Lp(a)

IDBP-388170

lipoprotein, Lp(a)

IDBP-808655

lipoprotein, Lp(a)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene is a serine proteinase that inhibits the activity of tissue-type plasminogen activator I. The encoded protein constitutes a substantial portion of lipoprotein(a) and is proteolytically cleaved, resulting in fragments that attach to atherosclerotic lesions and promote thrombogenesis. Elevated plasma levels of this protein are linked to atherosclerosis. Depending on the individual, the encoded protein contains 2-43 copies of kringle-type domains. The allele represented here contains 15 copies of the kringle-type repeats and corresponds to that found in the reference genome sequence. [provided by RefSeq, Dec 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 6:160531483-160664259

Strand

Reverse strand

Band

q26

Transcripts

ENST00000316300	ENSP00000321334
ENST00000447678	ENSP00000395608
ENST00000614786	ENSP00000480589

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.

Experimentally validated
Total	8 [view]
Protein-Protein	8 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001968	fibronectin binding
GO:0003824	catalytic activity
GO:0004175	endopeptidase activity
GO:0004252	serine-type endopeptidase activity
GO:0004866	endopeptidase inhibitor activity
GO:0005515	protein binding
GO:0008201	heparin binding
GO:0034185	apolipoprotein binding

Biological Process

GO:0006508	proteolysis
GO:0006629	lipid metabolic process
GO:0006869	lipid transport
GO:0006898	receptor-mediated endocytosis
GO:0008015	blood circulation
GO:0010951	negative regulation of endopeptidase activity
GO:0042157	lipoprotein metabolic process
GO:0042246	tissue regeneration
GO:0044281	small molecule metabolic process
GO:0045445	myoblast differentiation
GO:0046716	muscle cell cellular homeostasis
GO:0051603	proteolysis involved in cellular protein catabolic process
GO:0060707	trophoblast giant cell differentiation
GO:0060716	labyrinthine layer blood vessel development
GO:0071674	mononuclear cell migration

Cellular Component

GO:0005576	extracellular region
GO:0005886	plasma membrane
GO:0019897	extrinsic component of plasma membrane
GO:0034358	plasma lipoprotein particle
GO:0043231	intracellular membrane-bounded organelle

Orthologs

No orthologs found for this gene

Pathways

NETPATH

REACTOME

REACT_6934

LDL-mediated lipid transport pathway

REACT_22258

Metabolism of lipids and lipoproteins pathway

REACT_6823

Lipoprotein metabolism pathway

REACT_111217

Metabolism pathway

REACT_602

Lipid digestion, mobilization, and transport pathway

KEGG

INOH

PID NCI

amb2_neutrophils_pathway

amb2 Integrin signaling

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.520120

RefSeq

NM_005577

HUGO

OMIM

CCDS

CCDS43523

HPRD

01063

IMGT

EMBL

GenPept

RNA Seq Atlas