InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: LPA

Summary

InnateDB Protein

IDBP-98733.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

LPA

Protein Name

lipoprotein, Lp(a)

Synonyms

AK38; APOA; LP;

Species

Homo sapiens

Ensembl Protein

ENSP00000321334

InnateDB Gene

IDBG-98731 (LPA)

Protein Structure

UniProt Annotation

Function

Apo(a) is the main constituent of lipoprotein(a) (Lp(a)). It has serine proteinase activity and is able of autoproteolysis. Inhibits tissue-type plasminogen activator 1. Lp(a) may be a ligand for megalin/Gp 330. {ECO:0000269PubMed:2531657}.

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.

Experimentally validated
Total	8 [view]
Protein-Protein	8 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001968	fibronectin binding
GO:0003824	catalytic activity
GO:0004175	endopeptidase activity
GO:0004252	serine-type endopeptidase activity
GO:0004866	endopeptidase inhibitor activity
GO:0005515	protein binding
GO:0008201	heparin binding
GO:0034185	apolipoprotein binding

Biological Process

GO:0006508	proteolysis
GO:0006629	lipid metabolic process
GO:0006869	lipid transport
GO:0006898	receptor-mediated endocytosis
GO:0008015	blood circulation
GO:0010951	negative regulation of endopeptidase activity
GO:0042157	lipoprotein metabolic process
GO:0042246	tissue regeneration
GO:0044281	small molecule metabolic process
GO:0045445	myoblast differentiation
GO:0046716	muscle cell cellular homeostasis
GO:0051603	proteolysis involved in cellular protein catabolic process
GO:0060707	trophoblast giant cell differentiation
GO:0060716	labyrinthine layer blood vessel development
GO:0071674	mononuclear cell migration

Cellular Component

GO:0005576	extracellular region
GO:0005886	plasma membrane
GO:0019897	extrinsic component of plasma membrane
GO:0034358	plasma lipoprotein particle
GO:0043231	intracellular membrane-bounded organelle

Protein Structure and Domains

PDB ID

InterPro

IPR000001 Kringle
IPR001254 Peptidase S1
IPR001314 Peptidase S1A, chymotrypsin-type
IPR009003 Trypsin-like cysteine/serine peptidase domain
IPR013806 Kringle-like fold
IPR015420 Peptidase S1A, nudel

PFAM

PF00051
PF00089
PF09342

PRINTS

PR00722

PIRSF

SMART

SM00130
SM00020

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt