InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: DRD5

Summary

InnateDB Gene

IDBG-9881.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DRD5

Gene Name

dopamine receptor D5

Synonyms

DBDR; DRD1B; DRD1L2

Species

Homo sapiens

Ensembl Gene

ENSG00000169676

Encoded Proteins

IDBP-9885

dopamine receptor D5

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes the D5 subtype of the dopamine receptor. The D5 subtype is a G-protein coupled receptor which stimulates adenylyl cyclase. This receptor is expressed in neurons in the limbic regions of the brain. It has a 10-fold higher affinity for dopamine than the D1 subtype. Pseudogenes related to this gene reside on chromosomes 1 and 2. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 4:9781680-9784009

Strand

Forward strand

Band

p16.1

Transcripts

ENST00000304374

ENSP00000306129

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001588	dopamine receptor activity, coupled via Gs
GO:0004930	G-protein coupled receptor activity
GO:0004952	dopamine receptor activity
GO:0035240	dopamine binding

Biological Process

GO:0001963	synaptic transmission, dopaminergic
GO:0001975	response to amphetamine
GO:0001992	regulation of systemic arterial blood pressure by vasopressin
GO:0001994	norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure
GO:0006874	cellular calcium ion homeostasis
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007189	adenylate cyclase-activating G-protein coupled receptor signaling pathway
GO:0007190	activation of adenylate cyclase activity
GO:0007191	adenylate cyclase-activating dopamine receptor signaling pathway
GO:0007268	synaptic transmission
GO:0007617	mating behavior
GO:0008306	associative learning
GO:0010579	positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway
GO:0019226	transmission of nerve impulse
GO:0033861	negative regulation of NAD(P)H oxidase activity
GO:0042060	wound healing
GO:0042220	response to cocaine
GO:0045762	positive regulation of adenylate cyclase activity
GO:0045776	negative regulation of blood pressure
GO:0045924	regulation of female receptivity
GO:0046960	sensitization
GO:0060158	phospholipase C-activating dopamine receptor signaling pathway
GO:0060292	long term synaptic depression
GO:0071870	cellular response to catecholamine stimulus
GO:0072593	reactive oxygen species metabolic process