InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: DRD5

Summary

InnateDB Protein

IDBP-9885.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DRD5

Protein Name

dopamine receptor D5

Synonyms

DBDR; DRD1B; DRD1L2;

Species

Homo sapiens

Ensembl Protein

ENSP00000306129

InnateDB Gene

IDBG-9881 (DRD5)

Protein Structure

UniProt Annotation

Function

Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase. {ECO:0000269PubMed:1834671}.

Subcellular Localization

Cell membrane; Multi-pass membrane protein.

Disease Associations

Benign essential blepharospasm (BEB) [MIM:606798]: A primary focal dystonia affecting the orbicularis oculi muscles. Dystonia is defined by the presence of sustained involuntary muscle contraction, often leading to abnormal postures. BEB usually begins in middle age. Initial symptoms include eye irritation and frequent blinking, progressing to involuntary spasms of eyelid closure. Patients have normal eyes. The visual disturbance is due solely to the forced closure of the eyelids. In severe cases, this can lead to functional blindness. {ECO:0000269PubMed:11781417}. Note=Disease susceptibility may be associated with variations affecting the gene represented in this entry.

Tissue Specificity

Neuron-specific, localized primarily within limbic regions of the brain. {ECO:0000269PubMed:1834671}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001588	dopamine receptor activity, coupled via Gs
GO:0004930	G-protein coupled receptor activity
GO:0004952	dopamine receptor activity
GO:0035240	dopamine binding

Biological Process

GO:0001963	synaptic transmission, dopaminergic
GO:0001975	response to amphetamine
GO:0001992	regulation of systemic arterial blood pressure by vasopressin
GO:0001994	norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure
GO:0006874	cellular calcium ion homeostasis
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007189	adenylate cyclase-activating G-protein coupled receptor signaling pathway
GO:0007190	activation of adenylate cyclase activity
GO:0007191	adenylate cyclase-activating dopamine receptor signaling pathway
GO:0007268	synaptic transmission
GO:0007617	mating behavior
GO:0008306	associative learning
GO:0010579	positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway
GO:0019226	transmission of nerve impulse
GO:0033861	negative regulation of NAD(P)H oxidase activity
GO:0042060	wound healing
GO:0042220	response to cocaine
GO:0045762	positive regulation of adenylate cyclase activity
GO:0045776	negative regulation of blood pressure
GO:0045924	regulation of female receptivity
GO:0046960	sensitization
GO:0060158	phospholipase C-activating dopamine receptor signaling pathway
GO:0060292	long term synaptic depression
GO:0071870	cellular response to catecholamine stimulus
GO:0072593	reactive oxygen species metabolic process

Cellular Component

GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016021	integral component of membrane
GO:0031526	brush border membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000276 G protein-coupled receptor, rhodopsin-like
IPR000497 Dopamine D5 receptor
IPR000929 Dopamine receptor family
IPR017452 GPCR, rhodopsin-like, 7TM
IPR019424 7TM GPCR, olfactory receptor/chemoreceptor Srsx
IPR019430 7TM GPCR, serpentine receptor class x (Srx)

PFAM

PF00001
PF10320
PF10328

PRINTS

PR00237
PR00566
PR00242

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P21918