InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: PDE10A

Summary

InnateDB Gene

IDBG-98907.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PDE10A

Gene Name

phosphodiesterase 10A

Synonyms

HSPDE10A

Species

Homo sapiens

Ensembl Gene

ENSG00000112541

Encoded Proteins

IDBP-98909

phosphodiesterase 10A

IDBP-600575

phosphodiesterase 10A

IDBP-809088

phosphodiesterase 10A

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase family. It plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. This protein can hydrolyze both cAMP and cGMP to the corresponding nucleoside 5' monophosphate, but has higher affinity for cAMP, and is more efficient with cAMP as substrate. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Dec 2011]
The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase family. It plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. This protein can hydrolyze both cAMP and cGMP to the corresponding nucleoside 5\' monophosphate, but has higher affinity for cAMP, and is more efficient with cAMP as substrate. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Dec 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 6:165327287-165986603

Strand

Reverse strand

Band

q27

Transcripts

ENST00000366882	ENSP00000355847
ENST00000539869	ENSP00000438284
ENST00000616273	ENSP00000478556

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004114	3',5'-cyclic-nucleotide phosphodiesterase activity
GO:0004118	cGMP-stimulated cyclic-nucleotide phosphodiesterase activity
GO:0005515	protein binding
GO:0030552	cAMP binding
GO:0030553	cGMP binding
GO:0046872	metal ion binding
GO:0047555	3',5'-cyclic-GMP phosphodiesterase activity

Biological Process

GO:0006198	cAMP catabolic process
GO:0007165	signal transduction
GO:0007596	blood coagulation
GO:0010738	regulation of protein kinase A signaling
GO:0043949	regulation of cAMP-mediated signaling
GO:0046069	cGMP catabolic process