InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Pde10a

Summary

InnateDB Gene

IDBG-135818.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Pde10a

Gene Name

phosphodiesterase 10A

Synonyms

Species

Mus musculus

Ensembl Gene

ENSMUSG00000023868

Encoded Proteins

IDBP-135820

phosphodiesterase 10A

IDBP-135822

phosphodiesterase 10A

IDBP-249007

phosphodiesterase 10A

IDBP-249009

phosphodiesterase 10A

IDBP-249011

phosphodiesterase 10A

IDBP-787974

phosphodiesterase 10A

IDBP-249017

phosphodiesterase 10A

IDBP-249019

phosphodiesterase 10A

IDBP-539340

phosphodiesterase 10A

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000112541:
The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase family. It plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. This protein can hydrolyze both cAMP and cGMP to the corresponding nucleoside 5' monophosphate, but has higher affinity for cAMP, and is more efficient with cAMP as substrate. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Dec 2011]
The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase family. It plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. This protein can hydrolyze both cAMP and cGMP to the corresponding nucleoside 5\' monophosphate, but has higher affinity for cAMP, and is more efficient with cAMP as substrate. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Dec 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 17:8525372-8986648

Strand

Forward strand

Band

Transcripts

ENSMUST00000089085	ENSMUSP00000086485
ENSMUST00000024647	ENSMUSP00000024647
ENSMUST00000115724	ENSMUSP00000111389
ENSMUST00000115722	ENSMUSP00000111387
ENSMUST00000115720	ENSMUSP00000111385
ENSMUST00000115717	ENSMUSP00000138135
ENSMUST00000115715	ENSMUSP00000111380
ENSMUST00000115708	ENSMUSP00000111373
ENSMUST00000141877
ENSMUST00000136160
ENSMUST00000149440	ENSMUSP00000123216

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004114	3',5'-cyclic-nucleotide phosphodiesterase activity
GO:0004118	cGMP-stimulated cyclic-nucleotide phosphodiesterase activity
GO:0005515	protein binding
GO:0030552	cAMP binding
GO:0030553	cGMP binding
GO:0046872	metal ion binding
GO:0047555	3',5'-cyclic-GMP phosphodiesterase activity

Biological Process

GO:0006198	cAMP catabolic process
GO:0007165	signal transduction
GO:0008152	metabolic process
GO:0010738	regulation of protein kinase A signaling
GO:0043949	regulation of cAMP-mediated signaling
GO:0046069	cGMP catabolic process