Homo sapiens Gene: T

Summary
InnateDB Gene IDBG-98920.5
Last Modified 2012-02-14   [Report errors or provide feedback]
Gene Symbol T
Gene Name T, brachyury homolog (mouse)
Synonyms TFT
Species Homo sapiens
Ensembl Gene ENSG00000164458
Encoded Proteins
IDBP-98922 T, brachyury homolog (mouse)
IDBP-98924 T, brachyury homolog (mouse)
IDBP-98926 T, brachyury homolog (mouse)
IDBP-602684 T, brachyury homolog (mouse)
Entrez Gene
Summary The protein encoded by this gene is an embryonic nuclear transcription factor that binds to a specific DNA element, the palindromic T-site. It binds through a region in its N-terminus, called the T-box, and effects transcription of genes required for mesoderm formation and differentiation. The protein is localized to notochord-derived cells. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 6: 166571144-166582188
Strand Reverse strand
Band q27
Transcripts
ENST00000366876  ENSP00000355841
ENST00000296946  ENSP00000296946
ENST00000366871  ENSP00000355836
ENST00000461348  ENSP00000453512
Interactions
Number of Interactions   This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
 
Gene Ontology
Accession GO Term
Molecular Function
GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding
GO:0000981 sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0003705 RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
GO:0043565 sequence-specific DNA binding
Biological Process
GO:0001570 vasculogenesis
GO:0001756 somitogenesis
GO:0001839 neural plate morphogenesis
GO:0001843 neural tube closure
GO:0003007 heart morphogenesis
GO:0003257 positive regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation
GO:0006351 transcription, DNA-dependent
GO:0006355 regulation of transcription, DNA-dependent
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0006366 transcription from RNA polymerase II promoter
GO:0007165 signal transduction
GO:0007341 penetration of zona pellucida
GO:0007498 mesoderm development
GO:0007509 mesoderm migration involved in gastrulation
GO:0008284 positive regulation of cell proliferation
GO:0008595 anterior/posterior axis specification, embryo
GO:0009653 anatomical structure morphogenesis
GO:0009952 anterior/posterior pattern specification
GO:0014028 notochord formation
GO:0022414 reproductive process
GO:0023019 signal transduction involved in regulation of gene expression
GO:0030509 BMP signaling pathway
GO:0030903 notochord development
GO:0036342 post-anal tail morphogenesis
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048706 embryonic skeletal system development
GO:0055007 cardiac muscle cell differentiation
GO:0060070 canonical Wnt receptor signaling pathway
GO:0060349 bone morphogenesis
GO:0060395 SMAD protein signal transduction
GO:0061371 determination of heart left/right asymmetry
GO:0090009 primitive streak formation
Cellular Component
GO:0000785 chromatin
GO:0000790 nuclear chromatin
GO:0005634 nucleus
GO:0005737 cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID Gene Order Method Confidence Comments
ENSMUSG00000062327 Ortholuge Non-SSD Ortholog Possible paralog/unusual divergence/ gene prediction error
ENSBTAG00000018681 Not yet available Ortholuge Non-SSD Ortholog Possible paralog/unusual divergence/ gene prediction error
Pathways
NETPATH
REACTOME
KEGG
INOH
PID BIOCARTA
PID NCI
betacatenin_nuc_pathway Regulation of nuclear beta catenin signaling and target gene transcription
deltanp63pathway Validated transcriptional targets of deltaNp63 isoforms
Cross-References
SwissProt O15178 
TrEMBL E7ERD6 H0YM91 J3KP65
UniProt Splice Variant
Entrez Gene 6862 
UniGene Hs.389457
RefSeq NM_001270484  NM_003181 
HUGO 11515 
OMIM 601397
CCDS CCDS5290 
HPRD 03236
IMGT
EMBL AJ001699 AL627443 CH471051
GenPept CAA04938  CAI14269  EAW47539 
ImmGen T (murine) 
RNA Seq Atlas 6862