Version 5.4
Homo sapiens Gene: T
Summary
InnateDB Gene IDBG-98920.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol T
Gene Name T, brachyury homolog (mouse)
Synonyms SAVA; TFT
Species Homo sapiens
Ensembl Gene ENSG00000164458
Encoded Proteins
IDBP-98922
T, brachyury homolog (mouse)
IDBP-98924
T, brachyury homolog (mouse)
IDBP-98926
T, brachyury homolog (mouse)
IDBP-602684
T, brachyury homolog (mouse)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is an embryonic nuclear transcription factor that binds to a specific DNA element, the palindromic T-site. It binds through a region in its N-terminus, called the T-box, and effects transcription of genes required for mesoderm formation and differentiation. The protein is localized to notochord-derived cells. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:166157656-166168700
Strand Reverse strand
Band q27
Transcripts
ENST00000366876 ENSP00000355841
ENST00000296946 ENSP00000296946
ENST00000366871 ENSP00000355836
ENST00000461348 ENSP00000453512
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding
GO:0000981 sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0001085 RNA polymerase II transcription factor binding
GO:0001102 RNA polymerase II activating transcription factor binding
GO:0001191 RNA polymerase II transcription factor binding transcription factor activity involved in negative regulation of transcription
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0003705 RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
GO:0043565 sequence-specific DNA binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0001570 vasculogenesis
GO:0001756 somitogenesis
GO:0001839 neural plate morphogenesis
GO:0001843 neural tube closure
GO:0003007 heart morphogenesis
GO:0003257 positive regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0007165 signal transduction
GO:0007341 penetration of zona pellucida
GO:0007498 mesoderm development
GO:0007509 mesoderm migration involved in gastrulation
GO:0008284 positive regulation of cell proliferation
GO:0008595 anterior/posterior axis specification, embryo
GO:0009653 anatomical structure morphogenesis
GO:0009952 anterior/posterior pattern specification
GO:0014028 notochord formation
GO:0022414 reproductive process
GO:0023019 signal transduction involved in regulation of gene expression
GO:0030509 BMP signaling pathway
GO:0030903 notochord development
GO:0036342 post-anal tail morphogenesis
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048706 embryonic skeletal system development
GO:0060070 canonical Wnt signaling pathway
GO:0060349 bone morphogenesis
GO:0060395 SMAD protein signal transduction
GO:0061371 determination of heart left/right asymmetry
GO:0090009 primitive streak formation
Cellular Component
GO:0000785 chromatin
GO:0000790 nuclear chromatin
GO:0005634 nucleus
GO:0005737 cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000062327
View Gene Order
ENSBTAG00000018681
Not yet available
Pathways
NETPATH
REACTOME
KEGG
INOH
PID NCI
betacatenin_nuc_pathway
Regulation of nuclear beta catenin signaling and target gene transcription
deltanp63pathway
Validated transcriptional targets of deltaNp63 isoforms
Cross-References
SwissProt
TrEMBL H0YM91
UniProt Splice Variant
Entrez Gene 6862
UniGene Hs.389457
RefSeq NM_001270484 NM_003181
HUGO HGNC:11515
OMIM 601397
CCDS CCDS5290 CCDS59045
HPRD 03236
IMGT
EMBL AL627443
GenPept
RNA Seq Atlas 6862

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca