Version 5.4
Homo sapiens Gene: CYP2J2
Summary
InnateDB Gene IDBG-99271.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CYP2J2
Gene Name cytochrome P450, family 2, subfamily J, polypeptide 2
Synonyms CPJ2
Species Homo sapiens
Ensembl Gene ENSG00000134716
Encoded Proteins
IDBP-99273
cytochrome P450, family 2, subfamily J, polypeptide 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is thought to be the predominant enzyme responsible for epoxidation of endogenous arachidonic acid in cardiac tissue. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:59893308-59926790
Strand Reverse strand
Band p32.1
Transcripts
ENST00000371204 ENSP00000360247
ENST00000492633
ENST00000466095
ENST00000469406
ENST00000468257
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 2 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005506 iron ion binding
GO:0008392 arachidonic acid epoxygenase activity
GO:0008404 arachidonic acid 14,15-epoxygenase activity
GO:0008405 arachidonic acid 11,12-epoxygenase activity
GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0020037 heme binding
GO:0070330 aromatase activity
GO:0071614 linoleic acid epoxygenase activity
Biological Process
GO:0006690 icosanoid metabolic process
GO:0006805 xenobiotic metabolic process
GO:0008016 regulation of heart contraction
GO:0019369 arachidonic acid metabolic process
GO:0019373 epoxygenase P450 pathway
GO:0043651 linoleic acid metabolic process
GO:0044281 small molecule metabolic process
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005789 endoplasmic reticulum membrane
Orthologs
No orthologs found for this gene
Pathways
NETPATH
REACTOME
REACT_150417
Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) pathway
REACT_147851
Arachidonic acid metabolism pathway
REACT_13814
Fatty acids pathway
REACT_13543
Xenobiotics pathway
REACT_22258
Metabolism of lipids and lipoproteins pathway
REACT_13567
Cytochrome P450 - arranged by substrate type pathway
REACT_111217
Metabolism pathway
REACT_13433
Biological oxidations pathway
REACT_13705
Phase 1 - Functionalization of compounds pathway
KEGG
hsa00590
Arachidonic acid metabolism pathway
hsa00591
Linoleic acid metabolism pathway
INOH
INOH website
Tryptophan degradation pathway
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.152096
RefSeq NM_000775
HUGO
OMIM
CCDS CCDS613
HPRD 03159
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca