InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CYP2J2

Summary

InnateDB Protein

IDBP-99273.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CYP2J2

Protein Name

cytochrome P450, family 2, subfamily J, polypeptide 2

Synonyms

CPJ2;

Species

Homo sapiens

Ensembl Protein

ENSP00000360247

InnateDB Gene

IDBG-99271 (CYP2J2)

Protein Structure

UniProt Annotation

Function

This enzyme metabolizes arachidonic acid predominantly via a NADPH-dependent olefin epoxidation to all four regioisomeric cis-epoxyeicosatrienoic acids. One of the predominant enzymes responsible for the epoxidation of endogenous cardiac arachidonic acid pools.

Subcellular Localization

Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.

Disease Associations

Tissue Specificity

Highly expressed in heart, present at lower levels in liver, ileum, jejunum, colon, and kidney.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.

Experimentally validated
Total	3 [view]
Protein-Protein	2 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005506	iron ion binding
GO:0008392	arachidonic acid epoxygenase activity
GO:0008404	arachidonic acid 14,15-epoxygenase activity
GO:0008405	arachidonic acid 11,12-epoxygenase activity
GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0020037	heme binding
GO:0070330	aromatase activity
GO:0071614	linoleic acid epoxygenase activity

Biological Process

GO:0006690	icosanoid metabolic process
GO:0006805	xenobiotic metabolic process
GO:0008016	regulation of heart contraction
GO:0019369	arachidonic acid metabolic process
GO:0019373	epoxygenase P450 pathway
GO:0043651	linoleic acid metabolic process
GO:0044281	small molecule metabolic process
GO:0055114	oxidation-reduction process

Cellular Component

GO:0005789

endoplasmic reticulum membrane

Protein Structure and Domains

PDB ID

InterPro

IPR001128 Cytochrome P450
IPR002397 Cytochrome P450, B-class
IPR002401 Cytochrome P450, E-class, group I
IPR002403 Cytochrome P450, E-class, group IV
IPR008069 Cytochrome P450, E-class, group I, CYP2D-like
IPR008071 Cytochrome P450, E-class, group I, CYP2J-like

PFAM

PF00067

PRINTS

PR00385
PR00359
PR00463
PR00465
PR01686
PR01688

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P51589