InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: DLL1

Summary

InnateDB Gene

IDBG-99280.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DLL1

Gene Name

delta-like 1 (Drosophila)

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000198719

Encoded Proteins

IDBP-99282

delta-like 1 (Drosophila)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

DLL1 is a human homolog of the Notch Delta ligand and is a member of the delta/serrate/jagged family. It plays a role in mediating cell fate decisions during hematopoiesis. It may play a role in cell-to-cell communication. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 6:170282206-170290473

Strand

Reverse strand

Band

q27

Transcripts

ENST00000366756

ENSP00000355718

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.

Experimentally validated
Total	8 [view]
Protein-Protein	8 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	10 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005112	Notch binding
GO:0005509	calcium ion binding
GO:0005515	protein binding

Biological Process

GO:0001709	cell fate determination
GO:0001756	somitogenesis
GO:0001757	somite specification
GO:0001947	heart looping
GO:0007154	cell communication
GO:0007219	Notch signaling pathway
GO:0007220	Notch receptor processing
GO:0007267	cell-cell signaling
GO:0007275	multicellular organismal development
GO:0007368	determination of left/right symmetry
GO:0007386	compartment pattern specification
GO:0030097	hemopoiesis
GO:0030154	cell differentiation
GO:0030155	regulation of cell adhesion
GO:0032693	negative regulation of interleukin-10 production
GO:0045596	negative regulation of cell differentiation
GO:0045608	negative regulation of auditory receptor cell differentiation
GO:0045638	negative regulation of myeloid cell differentiation
GO:0045665	negative regulation of neuron differentiation
GO:0045747	positive regulation of Notch signaling pathway
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048839	inner ear development
GO:0050767	regulation of neurogenesis
GO:0070986	left/right axis specification
GO:0072014	proximal tubule development
GO:0072070	loop of Henle development
GO:0097150	neuronal stem cell maintenance

Cellular Component

GO:0005576	extracellular region
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0031410	cytoplasmic vesicle