InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: DLL1

Summary

InnateDB Protein

IDBP-99282.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DLL1

Protein Name

delta-like 1 (Drosophila)

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000355718

InnateDB Gene

IDBG-99280 (DLL1)

Protein Structure

UniProt Annotation

Function

Acts as a ligand for Notch receptors. Blocks the differentiation of progenitor cells into the B-cell lineage while promoting the emergence of a population of cells with the characteristics of a T-cell/NK-cell precursor. {ECO:0000269PubMed:11581320}.

Subcellular Localization

Membrane; Single-pass type I membrane protein.

Disease Associations

Tissue Specificity

Expressed in heart and pancreas, with lower expression in brain and muscle and almost no expression in placenta, lung, liver and kidney.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.

Experimentally validated
Total	8 [view]
Protein-Protein	8 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	10 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005112	Notch binding
GO:0005509	calcium ion binding
GO:0005515	protein binding

Biological Process

GO:0001709	cell fate determination
GO:0001756	somitogenesis
GO:0001757	somite specification
GO:0001947	heart looping
GO:0007154	cell communication
GO:0007219	Notch signaling pathway
GO:0007220	Notch receptor processing
GO:0007267	cell-cell signaling
GO:0007275	multicellular organismal development
GO:0007368	determination of left/right symmetry
GO:0007386	compartment pattern specification
GO:0030097	hemopoiesis
GO:0030154	cell differentiation
GO:0030155	regulation of cell adhesion
GO:0032693	negative regulation of interleukin-10 production
GO:0045596	negative regulation of cell differentiation
GO:0045608	negative regulation of auditory receptor cell differentiation
GO:0045638	negative regulation of myeloid cell differentiation
GO:0045665	negative regulation of neuron differentiation
GO:0045747	positive regulation of Notch signaling pathway
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048839	inner ear development
GO:0050767	regulation of neurogenesis
GO:0070986	left/right axis specification
GO:0072014	proximal tubule development
GO:0072070	loop of Henle development
GO:0097150	neuronal stem cell maintenance

Cellular Component

GO:0005576	extracellular region
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0031410	cytoplasmic vesicle

Protein Structure and Domains

PDB ID

InterPro

IPR000742 Epidermal growth factor-like domain
IPR001774 Delta/Serrate/lag-2 (DSL) protein
IPR001881 EGF-like calcium-binding domain
IPR011651 Notch ligand, N-terminal
IPR013111 EGF-like domain, extracellular

PFAM

PF00008
PF01414
PF07645
PF07657
PF07974

PRINTS

PIRSF

SMART

SM00181
SM00051
SM00179

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

O00548