Version 5.4
Homo sapiens Gene: PIGH
Summary
InnateDB Gene IDBG-9937.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PIGH
Gene Name phosphatidylinositol glycan anchor biosynthesis, class H
Synonyms GPI-H
Species Homo sapiens
Ensembl Gene ENSG00000100564
Encoded Proteins
IDBP-9939
phosphatidylinositol glycan anchor biosynthesis, class H
IDBP-589590
phosphatidylinositol glycan anchor biosynthesis, class H
IDBP-596138
phosphatidylinositol glycan anchor biosynthesis, class H
IDBP-583675
phosphatidylinositol glycan anchor biosynthesis, class H
IDBP-599215
phosphatidylinositol glycan anchor biosynthesis, class H
IDBP-588923
phosphatidylinositol glycan anchor biosynthesis, class H
IDBP-594324
phosphatidylinositol glycan anchor biosynthesis, class H
IDBP-586876
phosphatidylinositol glycan anchor biosynthesis, class H
IDBP-597487
phosphatidylinositol glycan anchor biosynthesis, class H
IDBP-591530
phosphatidylinositol glycan anchor biosynthesis, class H
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes an endoplasmic reticulum associated protein that is involved in glycosylphosphatidylinositol (GPI)-anchor biosynthesis. The GPI anchor is a glycolipid found on many blood cells and which serves to anchor proteins to the cell surface. The protein encoded by this gene is a subunit of the GPI N-acetylglucosaminyl (GlcNAc) transferase that transfers GlcNAc to phosphatidylinositol (PI) on the cytoplasmic side of the endoplasmic reticulum. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 14:67581955-67600287
Strand Reverse strand
Band q24.1
Transcripts
ENST00000216452 ENSP00000216452
ENST00000561272 ENSP00000453759
ENST00000558987 ENSP00000452816
ENST00000559118
ENST00000560722 ENSP00000453394
ENST00000558493 ENSP00000453158
ENST00000558198 ENSP00000452924
ENST00000561303 ENSP00000452974
ENST00000558001 ENSP00000454061
ENST00000559581 ENSP00000453733
ENST00000559415 ENSP00000452996
ENST00000559097
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
Experimentally validated
Total 5 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0017176 phosphatidylinositol N-acetylglucosaminyltransferase activity
Biological Process
GO:0006464 cellular protein modification process
GO:0006501 C-terminal protein lipidation
GO:0006506 GPI anchor biosynthetic process
GO:0008152 metabolic process
GO:0016254 preassembly of GPI anchor in ER membrane
GO:0043687 post-translational protein modification
GO:0044267 cellular protein metabolic process
Cellular Component
GO:0000506 glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000021120
View Gene Order
ENSBTAG00000018299
Not yet available
Pathways
NETPATH
REACTOME
REACT_952
Synthesis of glycosylphosphatidylinositol (GPI) pathway
REACT_1853
Post-translational modification: synthesis of GPI-anchored proteins pathway
REACT_22161
Post-translational protein modification pathway
REACT_17015
Metabolism of proteins pathway
KEGG
hsa00563
Glycosylphosphatidylinositol(GPI)-anchor biosynthesis pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.553497
RefSeq NM_004569 XM_006720172
HUGO
OMIM
CCDS CCDS9784
HPRD 02540
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca