InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: GNAL

Summary

InnateDB Gene

IDBG-995.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GNAL

Gene Name

guanine nucleotide binding protein (G protein), alpha activating activity polypeptide, olfactory type

Synonyms

DYT25

Species

Homo sapiens

Ensembl Gene

ENSG00000141404

Encoded Proteins

IDBP-997

guanine nucleotide binding protein (G protein), alpha activating activity polypeptide, olfactory type

IDBP-999

guanine nucleotide binding protein (G protein), alpha activating activity polypeptide, olfactory type

IDBP-363496

guanine nucleotide binding protein (G protein), alpha activating activity polypeptide, olfactory type

IDBP-584419

guanine nucleotide binding protein (G protein), alpha activating activity polypeptide, olfactory type

IDBP-727095

IDBP-727333

IDBP-726471

IDBP-812185

guanine nucleotide binding protein (G protein), alpha activating activity polypeptide, olfactory type

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a stimulatory G protein alpha subunit which mediates odorant signaling in the olfactory epithelium. This protein couples dopamine type 1 receptors and adenosine A2A receptors and is widely expressed in the central nervous system. Mutations in this gene have been associated with dystonia 25 and this gene is located in a susceptibility region for bipolar disorder and schizophrenia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 18:11688956-11885685

Strand

Forward strand

Band

p11.21

Transcripts

ENST00000334049	ENSP00000334051
ENST00000269162	ENSP00000269162
ENST00000423027	ENSP00000408489
ENST00000535121	ENSP00000439023
ENST00000590228	ENSP00000467709
ENST00000585590
ENST00000590972
ENST00000585642	ENSP00000467345
ENST00000586926	ENSP00000466709
ENST00000602628	ENSP00000473600

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.

Experimentally validated
Total	6 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001664	G-protein coupled receptor binding
GO:0003924	GTPase activity
GO:0004871	signal transducer activity
GO:0005525	GTP binding
GO:0019001	guanyl nucleotide binding
GO:0031683	G-protein beta/gamma-subunit complex binding
GO:0046872	metal ion binding

Biological Process

GO:0001975	response to amphetamine
GO:0006184	GTP catabolic process
GO:0007165	signal transduction
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007189	adenylate cyclase-activating G-protein coupled receptor signaling pathway
GO:0007190	activation of adenylate cyclase activity
GO:0007191	adenylate cyclase-activating dopamine receptor signaling pathway
GO:0007193	adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
GO:0007268	synaptic transmission
GO:0007608	sensory perception of smell
GO:0031000	response to caffeine