InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Gnal

Summary

InnateDB Gene

IDBG-155056.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Gnal

Gene Name

guanine nucleotide binding protein, alpha stimulating, olfactory type

Synonyms

2610011C15Rik; 9630020G10Rik; Galphaolf; Gna10; Golf

Species

Mus musculus

Ensembl Gene

ENSMUSG00000024524

Encoded Proteins

IDBP-155058

guanine nucleotide binding protein, alpha stimulating, olfactory type

IDBP-155060

guanine nucleotide binding protein, alpha stimulating, olfactory type

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000141404:
This gene encodes a stimulatory G protein alpha subunit which mediates odorant signaling in the olfactory epithelium. This protein couples dopamine type 1 receptors and adenosine A2A receptors and is widely expressed in the central nervous system. Mutations in this gene have been associated with dystonia 25 and this gene is located in a susceptibility region for bipolar disorder and schizophrenia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 18:67088336-67226792

Strand

Forward strand

Band

Transcripts

ENSMUST00000025402	ENSMUSP00000025402
ENSMUST00000076605	ENSMUSP00000075908

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001664	G-protein coupled receptor binding
GO:0003924	GTPase activity
GO:0004016	adenylate cyclase activity
GO:0004871	signal transducer activity
GO:0005525	GTP binding
GO:0019001	guanyl nucleotide binding
GO:0031683	G-protein beta/gamma-subunit complex binding
GO:0046872	metal ion binding

Biological Process

GO:0001975	response to amphetamine
GO:0006171	cAMP biosynthetic process
GO:0006184	GTP catabolic process
GO:0007165	signal transduction
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007189	adenylate cyclase-activating G-protein coupled receptor signaling pathway
GO:0007190	activation of adenylate cyclase activity
GO:0007191	adenylate cyclase-activating dopamine receptor signaling pathway
GO:0007608	sensory perception of smell
GO:0031000	response to caffeine