Version 5.4
Homo sapiens Gene: PIGK
Summary
InnateDB Gene IDBG-99796.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PIGK
Gene Name phosphatidylinositol glycan anchor biosynthesis, class K
Synonyms GPI8
Species Homo sapiens
Ensembl Gene ENSG00000142892
Encoded Proteins
IDBP-99800
phosphatidylinositol glycan anchor biosynthesis, class K
IDBP-99802
phosphatidylinositol glycan anchor biosynthesis, class K
IDBP-385946
phosphatidylinositol glycan anchor biosynthesis, class K
IDBP-812833
phosphatidylinositol glycan anchor biosynthesis, class K
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the cysteine protease family C13 that is involved in glycosylphosphatidylinositol (GPI)-anchor biosynthesis. The GPI-anchor is a glycolipid found on many blood cells and serves to anchor proteins to the cell surface. This protein is a member of the multisubunit enzyme, GPI transamidase and is thought to be its enzymatic component. GPI transamidase mediates GPI anchoring in the endoplasmic reticulum, by catalyzing the transfer of fully assembled GPI units to proteins. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:77088990-77219430
Strand Reverse strand
Band p31.1
Transcripts
ENST00000370812 ENSP00000359848
ENST00000359130 ENSP00000352041
ENST00000445065 ENSP00000388854
ENST00000487906 ENSP00000474518
ENST00000478391
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
Experimentally validated
Total 13 [view]
Protein-Protein 13 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003756 protein disulfide isomerase activity
GO:0003923 GPI-anchor transamidase activity
GO:0004197 cysteine-type endopeptidase activity
GO:0005515 protein binding
GO:0034235 GPI anchor binding
Biological Process
GO:0006457 protein folding
GO:0006501 C-terminal protein lipidation
GO:0006508 proteolysis
GO:0016255 attachment of GPI anchor to protein
GO:0043687 post-translational protein modification
GO:0044267 cellular protein metabolic process
Cellular Component
GO:0005789 endoplasmic reticulum membrane
GO:0016020 membrane
GO:0030176 integral component of endoplasmic reticulum membrane
GO:0042765 GPI-anchor transamidase complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000039047
View Gene Order
ENSBTAG00000031012
Not yet available
Pathways
NETPATH
REACTOME
REACT_1830
Attachment of GPI anchor to uPAR pathway
REACT_1853
Post-translational modification: synthesis of GPI-anchored proteins pathway
REACT_22161
Post-translational protein modification pathway
REACT_17015
Metabolism of proteins pathway
KEGG
hsa00563
Glycosylphosphatidylinositol(GPI)-anchor biosynthesis pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.178305
RefSeq NM_005482
HUGO
OMIM
CCDS CCDS674
HPRD 05474
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca