Version 5.4
Bos taurus Gene: PIGK
Summary
InnateDB Gene IDBG-637728.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PIGK
Gene Name GPI-anchor transamidase
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000031012
Encoded Proteins
IDBP-689756
GPI-anchor transamidase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000142892:
This gene encodes a member of the cysteine protease family C13 that is involved in glycosylphosphatidylinositol (GPI)-anchor biosynthesis. The GPI-anchor is a glycolipid found on many blood cells and serves to anchor proteins to the cell surface. This protein is a member of the multisubunit enzyme, GPI transamidase and is thought to be its enzymatic component. GPI transamidase mediates GPI anchoring in the endoplasmic reticulum, by catalyzing the transfer of fully assembled GPI units to proteins. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:67687802-67824632
Strand Forward strand
Band
Transcripts
ENSBTAT00000043893 ENSBTAP00000041428
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003923 GPI-anchor transamidase activity
GO:0004197 cysteine-type endopeptidase activity
GO:0005515 protein binding
GO:0008233 peptidase activity
GO:0008234 cysteine-type peptidase activity
GO:0016787 hydrolase activity
Biological Process
GO:0006506 GPI anchor biosynthetic process
GO:0006508 proteolysis
GO:0016255 attachment of GPI anchor to protein
Cellular Component
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0042765 GPI-anchor transamidase complex
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000142892
View Gene Order
ENSMUSG00000039047
View Gene Order
Pathways
NETPATH
REACTOME
REACT_223512
Post-translational modification: synthesis of GPI-anchored proteins pathway
REACT_213782
Metabolism of proteins pathway
REACT_214405
Post-translational protein modification pathway
REACT_226902
Attachment of GPI anchor to uPAR pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_1830
Attachment of GPI anchor to uPAR pathway
REACT_1853
Post-translational modification: synthesis of GPI-anchored proteins pathway
REACT_22161
Post-translational protein modification pathway
REACT_17015
Metabolism of proteins pathway
REACT_244576
Post-translational modification: synthesis of GPI-anchored proteins pathway
REACT_247926
Metabolism of proteins pathway
REACT_236283
Post-translational protein modification pathway
REACT_236590
Attachment of GPI anchor to uPAR pathway
KEGG
hsa00563
Glycosylphosphatidylinositol(GPI)-anchor biosynthesis pathway
mmu00563
Glycosylphosphatidylinositol(GPI)-anchor biosynthesis pathway
INOH
PID NCI
Cross-References
SwissProt Q3MHZ7
TrEMBL
UniProt Splice Variant
Entrez Gene 508700
UniGene Bt.67221
RefSeq NM_001077880
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC104506
GenPept AAI04507
RNA Seq Atlas 508700

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca