InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CLCA2

Summary

InnateDB Protein

IDBP-100080.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CLCA2

Protein Name

chloride channel accessory 2

Synonyms

CACC; CaCC-3; CACC3; CLCRG2;

Species

Homo sapiens

Ensembl Protein

ENSP00000359596

InnateDB Gene

IDBG-100078 (CLCA2)

Protein Structure

UniProt Annotation

Function

Plays a role in modulating chloride current across the plasma membrane in a calcium-dependent manner, and cell adhesion. Involved in basal cell adhesion and/or stratification of squamous epithelia. May act as a tumor suppressor in breast and colorectal cancer. Plays a key role for cell adhesion in the beginning stages of lung metastasis via the binding to ITGB4. {ECO:0000269PubMed:10554024, ECO:0000269PubMed:11320086, ECO:0000269PubMed:11445004, ECO:0000269PubMed:15707651, ECO:0000269PubMed:16158324}.

Subcellular Localization

Cell membrane; Single-pass type I membrane protein. Basal cell membrane; Single-pass type I membrane protein. Cell junction.Calcium-activated chloride channel regulator 2, 109 kDa form: Secreted. Note=Remains associated to the 35 kDa form until an unidentified event triggers the release.

Disease Associations

Tissue Specificity

Expressed in cornea, skin, vagina, esophagus, and larynx (at protein level). Expressed in trachea and mammary gland. Weakly expressed in testis and kidney. Highly expressed in corneal epithelium, colon and trachea. Moderately expressed in brain, urogenital organs, bladder, uterus and prostate. Highly expressed in tissues containing stratified epithelium including cornea, esophagus, larynx, skin and vagina than those tissues which contain only epithelial monolayers. Expressed in normal breast epithelium but not in breast cancer. Highly expressed during epithelial stratification. Expressed in endothelial cells of lung. Expressed selectively in endothelia of small pulmonary arteries, arterioles, and subpleural and interlobular venules. {ECO:0000269PubMed:10362588, ECO:0000269PubMed:10437792, ECO:0000269PubMed:10554024, ECO:0000269PubMed:11262615, ECO:0000269PubMed:11320086, ECO:0000269PubMed:14966209, ECO:0000269PubMed:15707651, ECO:0000269PubMed:16158324}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005254	chloride channel activity
GO:0015276	ligand-gated ion channel activity

Biological Process

GO:0006810	transport
GO:0006821	chloride transport
GO:0007155	cell adhesion
GO:0034220	ion transmembrane transport
GO:1902476	chloride transmembrane transport

Cellular Component

GO:0005576	extracellular region
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0009925	basal plasma membrane
GO:0030054	cell junction

Protein Structure and Domains

PDB ID

InterPro

IPR002035 von Willebrand factor, type A
IPR004727 Calcium-activated chloride channel protein
IPR013642 Chloride channel calcium-activated
IPR015394 Domain of unknown function DUF1973

PFAM

PF00092
PF08434
PF09315

PRINTS

PIRSF

SMART

SM00327

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9UQC9