InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CLCA1

Summary

InnateDB Protein

IDBP-100083.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CLCA1

Protein Name

chloride channel accessory 1

Synonyms

CACC; CaCC-1; CACC1; CLCRG1; GOB5; hCaCC-1; hCLCA1;

Species

Homo sapiens

Ensembl Protein

ENSP00000234701

InnateDB Gene

IDBG-100081 (CLCA1)

Protein Structure

UniProt Annotation

Function

May be involved in mediating calcium-activated chloride conductance. May play critical roles in goblet cell metaplasia, mucus hypersecretion, cystic fibrosis and AHR. May be involved in the regulation of mucus production and/or secretion by goblet cells. Involved in the regulation of tissue inflammation in the innate immune response. May play a role as a tumor suppressor. Induces MUC5AC. {ECO:0000269PubMed:11445004, ECO:0000269PubMed:11842292, ECO:0000269PubMed:11956057, ECO:0000269PubMed:9828122}.

Subcellular Localization

Secreted, extracellular space {ECO:0000269PubMed:15919655}. Cell membrane {ECO:0000269PubMed:15919655}; Peripheral membrane protein {ECO:0000269PubMed:15919655}; Extracellular side {ECO:0000269PubMed:15919655}. Note=Protein that remains attached to the plasma membrane appeared to be predominantly localized to microvilli.

Disease Associations

Tissue Specificity

Highly expressed in small intestine and colon namely in intestinal basal crypt epithelia and goblet cells, and appendix. Weakly expressed in uterus, testis and kidney. Expressed in the airways epithelium of both asthmatic and healthy patients. Expressed in the bronchial epithelium, especially in mucus- producing goblet cells. Expressed in normal turbinate mucosa and nasal polyp. Expressed in. {ECO:0000269PubMed:10437792, ECO:0000269PubMed:11842292, ECO:0000269PubMed:11956057, ECO:0000269PubMed:16012037, ECO:0000269PubMed:9828122}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005254	chloride channel activity
GO:0005515	protein binding

Biological Process

GO:0006810	transport
GO:0006816	calcium ion transport
GO:0006821	chloride transport
GO:0071456	cellular response to hypoxia
GO:1902476	chloride transmembrane transport

Cellular Component

GO:0005615	extracellular space
GO:0005887	integral component of plasma membrane
GO:0005902	microvillus
GO:0016021	integral component of membrane
GO:0030141	secretory granule
GO:0042589	zymogen granule membrane

Protein Structure and Domains

PDB ID

InterPro

IPR002035 von Willebrand factor, type A
IPR003961 Fibronectin, type III
IPR004727 Calcium-activated chloride channel protein
IPR013642 Chloride channel calcium-activated
IPR015394 Domain of unknown function DUF1973

PFAM

PF00092
PF00041
PF01108
PF08434
PF09315

PRINTS

PIRSF

SMART

SM00327
SM00060

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

A8K7I4