Version 5.4
Homo sapiens Gene: CLCA1
Summary
InnateDB Gene IDBG-100081.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CLCA1
Gene Name chloride channel accessory 1
Synonyms CACC; CaCC-1; CACC1; CLCRG1; GOB5; hCaCC-1; hCLCA1
Species Homo sapiens
Ensembl Gene ENSG00000016490
Encoded Proteins
IDBP-100083
chloride channel accessory 1
IDBP-241026
chloride channel accessory 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the calcium sensitive chloride conductance protein family. To date, all members of this gene family map to the same region on chromosome 1p31-p22 and share a high degree of homology in size, sequence, and predicted structure, but differ significantly in their tissue distributions. The encoded protein is expressed as a precursor protein that is processed into two cell-surface-associated subunits, although the site at which the precursor is cleaved has not been precisely determined. The encoded protein may be involved in mediating calcium-activated chloride conductance in the intestine. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:86468368-86500289
Strand Forward strand
Band p22.3
Transcripts
ENST00000234701 ENSP00000234701
ENST00000394711 ENSP00000378200
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005254 chloride channel activity
GO:0005515 protein binding
Biological Process
GO:0006810 transport
GO:0006816 calcium ion transport
GO:0006821 chloride transport
GO:0071456 cellular response to hypoxia
GO:1902476 chloride transmembrane transport
Cellular Component
GO:0005615 extracellular space
GO:0005887 integral component of plasma membrane
GO:0005902 microvillus
GO:0016021 integral component of membrane
GO:0030141 secretory granule
GO:0042589 zymogen granule membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000028255
View Gene Order
ENSBTAG00000008161
Not yet available
Pathways
NETPATH
NetPath_1
Alpha6Beta4Integrin pathway
REACTOME
REACT_160189
Stimuli-sensing channels pathway
REACT_15518
Transmembrane transport of small molecules pathway
REACT_267716
Orphan transporters pathway
REACT_25300
Ion channel transport pathway
KEGG
hsa04740
Olfactory transduction pathway
hsa04972
Pancreatic secretion pathway
INOH
PID NCI
Cross-References
SwissProt A8K7I4
TrEMBL
UniProt Splice Variant
Entrez Gene 1179
UniGene Hs.194659 Hs.606218
RefSeq NM_001285
HUGO HGNC:2015
OMIM 603906
CCDS CCDS709
HPRD
IMGT
EMBL AF039400 AF039401 AF127036 AK291999 AK314375 AL122002 CH471097
GenPept AAC95428 AAC95429 AAD25487 BAF84688 BAG37002 CAI22169 EAW73186
RNA Seq Atlas 1179

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca