Version 5.4
Homo sapiens Protein: CLCA4
Summary
InnateDB Protein IDBP-100086.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CLCA4
Protein Name chloride channel accessory 4
Synonyms CaCC; CaCC2;
Species Homo sapiens
Ensembl Protein ENSP00000359594
InnateDB Gene IDBG-100084 (CLCA4)
Protein Structure
UniProt Annotation
Function May be involved in mediating calcium-activated chloride conductance.
Subcellular Localization Cell membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}. Apical cell membrane {ECO:0000250}. Secreted {ECO:0000250}. Note=The C-terminus 30 kDa form is anchored to the membrane. The N-terminus 110 kDa form is released from the membrane triggered by an unknown stimulus. {ECO:0000250}.
Disease Associations
Tissue Specificity Primarily expressed in the digestive tract, mainly in colon. Detected in smaller amounts in brain, urogenital organs, testis, and salivary and mammary glands. Highly expressed in the epithelial layer and submucosal gland of the inferior turbinate mucosa. Lower levels in the epithelial layer of nasal polyp. {ECO:0000269PubMed:10437792, ECO:0000269PubMed:15490240, ECO:0000269PubMed:16012037}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0005254 chloride channel activity
GO:0005515 protein binding
Biological Process
GO:0006810 transport
GO:0006821 chloride transport
GO:1902476 chloride transmembrane transport
Cellular Component
GO:0005887 integral component of plasma membrane
GO:0016324 apical plasma membrane
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR002035 von Willebrand factor, type A
IPR003961 Fibronectin, type III
IPR004727 Calcium-activated chloride channel protein
IPR013642 Chloride channel calcium-activated
IPR015394 Domain of unknown function DUF1973
PFAM PF00092
PF00041
PF01108
PF08434
PF09315
PRINTS
PIRSF
SMART SM00327
SM00060
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q14CN2
PhosphoSite PhosphoSite-Q14CN2
TrEMBL Q9NXP1
UniProt Splice Variant
Entrez Gene 22802
UniGene Hs.607191
RefSeq NP_036260
HUGO HGNC:2018
OMIM
CCDS CCDS41355
HPRD 16719
IMGT
EMBL AF127035 AK000138 AL122002 AY358470 BC113687 BC113689
GenPept AAD48398 AAI13688 AAI13690 AAQ88834 BAA90969 CAI22170

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca