Version 5.4
Homo sapiens Protein: GBP4
Summary
InnateDB Protein IDBP-100179.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GBP4
Protein Name guanylate binding protein 4
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000359490
InnateDB Gene IDBG-100177 (GBP4)
Protein Structure
UniProt Annotation
Function Binds GTP, GDP and GMP. Hydrolyzes GTP very efficiently; GDP rather than GMP is the major reaction product. Plays a role in erythroid differentiation (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm {ECO:0000269PubMed:17266443}. Nucleus {ECO:0000269PubMed:17266443}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0003924 GTPase activity
GO:0005525 GTP binding
Biological Process
GO:0006184 GTP catabolic process
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID
InterPro IPR003191 Guanylate-binding protein, C-terminal
IPR015894 Guanylate-binding protein, N-terminal
IPR027417 P-loop containing nucleoside triphosphate hydrolase
PFAM PF02841
PF02263
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q96PP9
PhosphoSite PhosphoSite-Q96PP9
TrEMBL B4E2F1
UniProt Splice Variant
Entrez Gene 115361
UniGene Hs.409925
RefSeq NP_443173
HUGO HGNC:20480
OMIM 612466
CCDS CCDS721
HPRD 13570
IMGT
EMBL AF288814 AK131094 AK304245 AK312417 AL832576 BC017889 BC070055
GenPept AAH17889 AAH70055 AAL02054 BAC85144 BAG35327 BAG65113 CAD89936

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca