InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: DR1

Summary

InnateDB Protein

IDBP-100331.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DR1

Protein Name

down-regulator of transcription 1, TBP-binding (negative cofactor 2)

Synonyms

NC2; NC2-BETA;

Species

Homo sapiens

Ensembl Protein

ENSP00000359295

InnateDB Gene

IDBG-100329 (DR1)

Protein Structure

UniProt Annotation

Function

The association of the DR1/DRAP1 heterodimer with TBP results in a functional repression of both activated and basal transcription of class II genes. This interaction precludes the formation of a transcription-competent complex by inhibiting the association of TFIIA and/or TFIIB with TBP. Can bind to DNA on its own. Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4. {ECO:0000269PubMed:19103755, ECO:0000269PubMed:8670811}.

Subcellular Localization

Nucleus.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 41 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	41 [view]
Protein-Protein	38 [view]
Protein-DNA	2 [view]
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003714	transcription corepressor activity
GO:0005515	protein binding
GO:0008134	transcription factor binding
GO:0017025	TBP-class protein binding
GO:0043565	sequence-specific DNA binding
GO:0046982	protein heterodimerization activity

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006325	chromatin organization
GO:0006351	transcription, DNA-templated
GO:0043966	histone H3 acetylation
GO:0045087	innate immune response (InnateDB)