InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: DR1

Summary

InnateDB Gene

IDBG-100329.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DR1

Gene Name

down-regulator of transcription 1, TBP-binding (negative cofactor 2)

Synonyms

NC2; NC2-BETA

Species

Homo sapiens

Ensembl Gene

ENSG00000117505

Encoded Proteins

IDBP-100331

down-regulator of transcription 1, TBP-binding (negative cofactor 2)

IDBP-100333

down-regulator of transcription 1, TBP-binding (negative cofactor 2)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 25589657

DR1, a novel host susceptibility gene for influenza A virus replication, suppresses host innate immunity and enhances viral RNA replication.

Entrez Gene

Summary

This gene encodes a TBP- (TATA box-binding protein) associated phosphoprotein that represses both basal and activated levels of transcription. The encoded protein is phosphorylated in vivo and this phosphorylation affects its interaction with TBP. This protein contains a histone fold motif at the amino terminus, a TBP-binding domain, and a glutamine- and alanine-rich region. The binding of DR1 repressor complexes to TBP-promoter complexes may establish a mechanism in which an altered DNA conformation, together with the formation of higher order complexes, inhibits the assembly of the preinitiation complex and controls the rate of RNA polymerase II transcription. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:93345888-93369498

Strand

Forward strand

Band

p22.1

Transcripts

ENST00000370272	ENSP00000359295
ENST00000370267	ENSP00000359290
ENST00000481583

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 41 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	41 [view]
Protein-Protein	38 [view]
Protein-DNA	2 [view]
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003714	transcription corepressor activity
GO:0005515	protein binding
GO:0008134	transcription factor binding
GO:0017025	TBP-class protein binding
GO:0043565	sequence-specific DNA binding
GO:0046982	protein heterodimerization activity

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006325	chromatin organization
GO:0006351	transcription, DNA-templated
GO:0043966	histone H3 acetylation
GO:0045087	innate immune response (InnateDB)

Cellular Component

GO:0005622	intracellular
GO:0005634	nucleus
GO:0005671	Ada2/Gcn5/Ada3 transcription activator complex

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000029265

View Gene Order

ENSBTAG00000008737

Not yet available

Pathways

NETPATH

REACTOME

REACT_172610

HATs acetylate histones pathway

REACT_172623

Chromatin organization pathway

REACT_172633

Chromatin modifying enzymes pathway

KEGG

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.348418 Hs.599945

RefSeq

NM_001938

HUGO

OMIM

CCDS

CCDS744

HPRD

03284

IMGT

EMBL

GenPept

RNA Seq Atlas