InnateDB Protein
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IDBP-100333.5
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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DR1
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Protein Name
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down-regulator of transcription 1, TBP-binding (negative cofactor 2)
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Synonyms
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NC2; NC2-BETA;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000359290
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InnateDB Gene
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IDBG-100329 (DR1)
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Protein Structure
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Function |
The association of the DR1/DRAP1 heterodimer with TBP results in a functional repression of both activated and basal transcription of class II genes. This interaction precludes the formation of a transcription-competent complex by inhibiting the association of TFIIA and/or TFIIB with TBP. Can bind to DNA on its own. Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4. {ECO:0000269PubMed:19103755, ECO:0000269PubMed:8670811}.
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Subcellular Localization |
Nucleus.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 41 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated |
Total |
41
[view]
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Protein-Protein |
38
[view]
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Protein-DNA |
2
[view]
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Protein-RNA |
1
[view]
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
1 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR003958
Transcription factor CBF/NF-Y/archaeal histone
IPR009072
Histone-fold
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PFAM |
PF00808
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q01658
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PhosphoSite |
PhosphoSite-Q01658
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TrEMBL |
Q658N3
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UniProt Splice Variant |
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Entrez Gene |
1810
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UniGene |
Hs.599945
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RefSeq |
NP_001929
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HUGO |
HGNC:3017
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OMIM |
601482
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CCDS |
CCDS744
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HPRD |
03284
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IMGT |
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EMBL |
AK057541
AL137159
AL833729
BC002809
BC035507
BC068553
BT006972
CH471097
M97388
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GenPept |
AAA58442
AAH02809
AAH35507
AAH68553
AAP35618
BAG51931
CAC17578
CAH56250
EAW73072
EAW73073
EAW73074
EAW73075
EAW73076
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