InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: BCAR3

Summary

InnateDB Protein

IDBP-100347.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BCAR3

Protein Name

breast cancer anti-estrogen resistance 3

Synonyms

NSP2; SH2D3B;

Species

Homo sapiens

Ensembl Protein

ENSP00000359264

InnateDB Gene

IDBG-100343 (BCAR3)

Protein Structure

UniProt Annotation

Function

May act as an adapter protein and couple activated growth factor receptors to a signaling pathway that regulates the proliferation in breast cancer cells. When overexpressed, it confers anti-estrogen resistance in breast cancer cell lines. May also be regulated by cellular adhesion to extracellular matrix proteins. {ECO:0000269PubMed:9582273}.

Subcellular Localization

Disease Associations

Tissue Specificity

Ubiquitously expressed. Found in several cancer cell lines, but not in nonmalignant breast tissue. {ECO:0000269PubMed:10187783, ECO:0000269PubMed:9582273}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.

Experimentally validated
Total	16 [view]
Protein-Protein	16 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005085	guanyl-nucleotide exchange factor activity
GO:0005515	protein binding

Biological Process

GO:0002089	lens morphogenesis in camera-type eye
GO:0007165	signal transduction
GO:0007264	small GTPase mediated signal transduction
GO:0033138	positive regulation of peptidyl-serine phosphorylation
GO:0042493	response to drug
GO:0043547	positive regulation of GTPase activity