Version 5.4
Homo sapiens Gene: BCAR3
Summary
InnateDB Gene IDBG-100343.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol BCAR3
Gene Name breast cancer anti-estrogen resistance 3
Synonyms NSP2; SH2D3B
Species Homo sapiens
Ensembl Gene ENSG00000137936
Encoded Proteins
IDBP-100345
breast cancer anti-estrogen resistance 3
IDBP-100347
breast cancer anti-estrogen resistance 3
IDBP-100349
breast cancer anti-estrogen resistance 3
IDBP-100351
breast cancer anti-estrogen resistance 3
IDBP-596159
breast cancer anti-estrogen resistance 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Breast tumors are initially dependent on estrogens for growth and progression and can be inhibited by anti-estrogens such as tamoxifen. However, breast cancers progress to become anti-estrogen resistant. Breast cancer anti-estrogen resistance gene 3 was identified in the search for genes involved in the development of estrogen resistance. The gene encodes a component of intracellular signal transduction that causes estrogen-independent proliferation in human breast cancer cells. The protein contains a putative src homology 2 (SH2) domain, a hall mark of cellular tyrosine kinase signaling molecules, and is partly homologous to the cell division cycle protein CDC48. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:93561786-93847150
Strand Reverse strand
Band p22.1
Transcripts
ENST00000370247 ENSP00000359267
ENST00000370244 ENSP00000359264
ENST00000260502 ENSP00000260502
ENST00000370243 ENSP00000359263
ENST00000466632
ENST00000490377
ENST00000479503
ENST00000469315
ENST00000538653
ENST00000539242 ENSP00000441343
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.
Experimentally validated
Total 16 [view]
Protein-Protein 16 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005085 guanyl-nucleotide exchange factor activity
GO:0005515 protein binding
Biological Process
GO:0002089 lens morphogenesis in camera-type eye
GO:0007165 signal transduction
GO:0007264 small GTPase mediated signal transduction
GO:0033138 positive regulation of peptidyl-serine phosphorylation
GO:0042493 response to drug
GO:0043547 positive regulation of GTPase activity
Cellular Component
GO:0005622 intracellular
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000028121
View Gene Order
ENSBTAG00000003245
Not yet available
Pathways
NETPATH
NetPath_4
EGFR1 pathway
REACTOME
KEGG
INOH
PID NCI
cdc42_reg_pathway
Regulation of CDC42 activity
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.36958
RefSeq NM_001261408 NM_001261409 NM_001261410 NM_003567
HUGO
OMIM
CCDS CCDS58010 CCDS745
HPRD 05268
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca