InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: F3

Summary

InnateDB Protein

IDBP-100380.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Protein Name

coagulation factor III (thromboplastin, tissue factor)

Synonyms

CD142; TF; TFA;

Species

Homo sapiens

Ensembl Protein

ENSP00000334145

InnateDB Gene

IDBG-100378 (F3)

Protein Structure

UniProt Annotation

Function

Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex activates factors IX or X by specific limited protolysis. TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade. {ECO:0000269PubMed:12652293}.

Subcellular Localization

Isoform 1: Membrane; Single-pass type I membrane protein.Isoform 2: Secreted.

Disease Associations

Tissue Specificity

Lung, placenta and pancreas. {ECO:0000269PubMed:12652293}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.

Experimentally validated
Total	7 [view]
Protein-Protein	7 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0002020	protease binding
GO:0005515	protein binding
GO:0005543	phospholipid binding

Biological Process

GO:0001938	positive regulation of endothelial cell proliferation
GO:0002541	activation of plasma proteins involved in acute inflammatory response
GO:0002543	activation of blood coagulation via clotting cascade
GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0007596	blood coagulation
GO:0007598	blood coagulation, extrinsic pathway
GO:0010641	positive regulation of platelet-derived growth factor receptor signaling pathway
GO:0030335	positive regulation of cell migration
GO:0045766	positive regulation of angiogenesis
GO:0050927	positive regulation of positive chemotaxis
GO:0051897	positive regulation of protein kinase B signaling

Cellular Component

GO:0005615	extracellular space
GO:0005886	plasma membrane
GO:0009986	cell surface
GO:0016021	integral component of membrane
GO:0031012	extracellular matrix
GO:0031233	intrinsic to external side of plasma membrane
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR001187 Tissue factor
IPR003961 Fibronectin, type III
IPR015373 Interferon alpha/beta receptor, beta chain
IPR016354 Tissue factor/coagulation factor III

PFAM

PF00041
PF01108
PF09294

PRINTS

PR00346

PIRSF

PIRSF002498

SMART

SM00060

TIGRFAMs

Post-translational Modifications

Modification

Cross-References