InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CDC14A

Summary

InnateDB Protein

IDBP-100515.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CDC14A

Protein Name

CDC14 cell division cycle 14 homolog A (S. cerevisiae)

Synonyms

cdc14; hCDC14;

Species

Homo sapiens

Ensembl Protein

ENSP00000336739

InnateDB Gene

IDBG-100511 (CDC14A)

Protein Structure

UniProt Annotation

Function

Dual-specificity phosphatase. Required for centrosome separation and productive cytokinesis during cell division. Dephosphorylates SIRT2 around early anaphase. May dephosphorylate the APC subunit FZR1/CDH1, thereby promoting APC-FZR1 dependent degradation of mitotic cyclins and subsequent exit from mitosis. {ECO:0000269PubMed:11901424, ECO:0000269PubMed:12134069, ECO:0000269PubMed:17488717, ECO:0000269PubMed:9367992}.

Subcellular Localization

Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Note=Centrosomal during interphase, released into the cytoplasm at the onset of mitosis. Subsequently localizes to the midzone of the mitotic spindle.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.

Experimentally validated
Total	16 [view]
Protein-Protein	14 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004721	phosphoprotein phosphatase activity
GO:0004725	protein tyrosine phosphatase activity
GO:0005515	protein binding
GO:0008138	protein tyrosine/serine/threonine phosphatase activity
GO:0016791	phosphatase activity

Biological Process

GO:0006470	protein dephosphorylation
GO:0007049	cell cycle
GO:0008283	cell proliferation
GO:0016311	dephosphorylation
GO:0035335	peptidyl-tyrosine dephosphorylation
GO:0051301	cell division

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005813	centrosome
GO:0005819	spindle

Protein Structure and Domains

PDB ID

InterPro

IPR000242 Protein-tyrosine phosphatase, receptor/non-receptor type
IPR000340 Dual specificity phosphatase, catalytic domain
IPR000387 Protein-tyrosine/Dual specificity phosphatase
IPR003595 Protein-tyrosine phosphatase, catalytic
IPR020422 Dual specificity phosphatase, subgroup, catalytic domain
IPR029021 Protein-tyrosine phosphatase-like

PFAM

PF00102
PF00782

PRINTS

PR00700

PIRSF

SMART

SM00194
SM00404
SM00195

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt