Version 5.4
| Homo sapiens Gene: CDC14A | |||||||||||||||||||
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| Summary | |||||||||||||||||||
| InnateDB Gene | IDBG-100511.6 | ||||||||||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||
| Gene Symbol | CDC14A | ||||||||||||||||||
| Gene Name | CDC14 cell division cycle 14 homolog A (S. cerevisiae) | ||||||||||||||||||
| Synonyms | cdc14; hCDC14 | ||||||||||||||||||
| Species | Homo sapiens | ||||||||||||||||||
| Ensembl Gene | ENSG00000079335 | ||||||||||||||||||
| Encoded Proteins |
CDC14 cell division cycle 14 homolog A (S. cerevisiae)
CDC14 cell division cycle 14 homolog A (S. cerevisiae)
CDC14 cell division cycle 14 homolog A (S. cerevisiae)
CDC14 cell division cycle 14 homolog A (S. cerevisiae)
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| Protein Structure |
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| Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||
| Entrez Gene | |||||||||||||||||||
| Summary |
The protein encoded by this gene is a member of the dual specificity protein tyrosine phosphatase family. It is highly similar to Saccharomyces cerevisiae Cdc14, a protein tyrosine phosphatase involved in the exit of cell mitosis and initiation of DNA replication, suggesting a role in cell cycle control. This protein has been shown to interact with, and dephosphorylate tumor suppressor protein p53, and is thought to regulate the function of p53. Alternative splicing of this gene results in several transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008] |
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| Gene Information | |||||||||||||||||||
| Type | Protein coding | ||||||||||||||||||
| Genomic Location | Chromosome 1:100351734-100520277 | ||||||||||||||||||
| Strand | Forward strand | ||||||||||||||||||
| Band | p21.2 | ||||||||||||||||||
| Transcripts |
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| Interactions | |||||||||||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.
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| Gene Ontology | |||||||||||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||||||||||||
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Species
Mus musculus
Bos taurus
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Gene ID
Gene Order
Not yet available
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| Pathways | |||||||||||||||||||
| NETPATH | |||||||||||||||||||
| REACTOME |
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase pathway
APC/C-mediated degradation of cell cycle proteins pathway
Regulation of mitotic cell cycle pathway
Cell Cycle pathway
Cell Cycle, Mitotic pathway
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| KEGG |
Cell cycle pathway
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| INOH | |||||||||||||||||||
| PID NCI | |||||||||||||||||||
| Cross-References | |||||||||||||||||||
| SwissProt | Q9UNH5 | ||||||||||||||||||
| TrEMBL | |||||||||||||||||||
| UniProt Splice Variant | |||||||||||||||||||
| Entrez Gene | 8556 | ||||||||||||||||||
| UniGene | Hs.127411 Hs.595148 | ||||||||||||||||||
| RefSeq | NM_003672 XM_005271296 NM_033312 NM_033313 XM_005271294 | ||||||||||||||||||
| HUGO | HGNC:1718 | ||||||||||||||||||
| OMIM | 603504 | ||||||||||||||||||
| CCDS | CCDS769 CCDS770 CCDS771 | ||||||||||||||||||
| HPRD | 04614 | ||||||||||||||||||
| IMGT | |||||||||||||||||||
| EMBL | AC104457 AF000367 AF064102 AF064103 AF122013 AL589990 AY623111 BC038979 BC093916 BC093918 CH471097 DQ530256 | ||||||||||||||||||
| GenPept | AAB88277 AAC16659 AAC16660 AAD49217 AAH38979 AAH93916 AAH93918 AAT38107 ABF74568 CAH70068 CAH70069 CAH70070 EAW72956 EAW72958 EAW72959 | ||||||||||||||||||
| RNA Seq Atlas | 8556 | ||||||||||||||||||