Homo sapiens Protein: CDC14A | |||||||||||||||||||
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Summary | |||||||||||||||||||
InnateDB Protein | IDBP-100521.7 | ||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||
Gene Symbol | CDC14A | ||||||||||||||||||
Protein Name | CDC14 cell division cycle 14 homolog A (S. cerevisiae) | ||||||||||||||||||
Synonyms | cdc14; hCDC14; | ||||||||||||||||||
Species | Homo sapiens | ||||||||||||||||||
Ensembl Protein | ENSP00000359142 | ||||||||||||||||||
InnateDB Gene | IDBG-100511 (CDC14A) | ||||||||||||||||||
Protein Structure | |||||||||||||||||||
UniProt Annotation | |||||||||||||||||||
Function | Dual-specificity phosphatase. Required for centrosome separation and productive cytokinesis during cell division. Dephosphorylates SIRT2 around early anaphase. May dephosphorylate the APC subunit FZR1/CDH1, thereby promoting APC-FZR1 dependent degradation of mitotic cyclins and subsequent exit from mitosis. {ECO:0000269PubMed:11901424, ECO:0000269PubMed:12134069, ECO:0000269PubMed:17488717, ECO:0000269PubMed:9367992}. | ||||||||||||||||||
Subcellular Localization | Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Note=Centrosomal during interphase, released into the cytoplasm at the onset of mitosis. Subsequently localizes to the midzone of the mitotic spindle. | ||||||||||||||||||
Disease Associations | |||||||||||||||||||
Tissue Specificity | |||||||||||||||||||
Comments | |||||||||||||||||||
Interactions | |||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.
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Gene Ontology | |||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Protein Structure and Domains | |||||||||||||||||||
PDB ID | |||||||||||||||||||
InterPro |
IPR000242
Protein-tyrosine phosphatase, receptor/non-receptor type IPR000340 Dual specificity phosphatase, catalytic domain IPR000387 Protein-tyrosine/Dual specificity phosphatase IPR003595 Protein-tyrosine phosphatase, catalytic IPR020422 Dual specificity phosphatase, subgroup, catalytic domain IPR029021 Protein-tyrosine phosphatase-like |
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PFAM |
PF00102
PF00782 |
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PRINTS |
PR00700
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PIRSF | |||||||||||||||||||
SMART |
SM00194
SM00404 SM00195 |
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TIGRFAMs | |||||||||||||||||||
Post-translational Modifications | |||||||||||||||||||
Modification | |||||||||||||||||||
Cross-References | |||||||||||||||||||
SwissProt | Q9UNH5 | ||||||||||||||||||
PhosphoSite | PhosphoSite-Q9UNH5 | ||||||||||||||||||
TrEMBL | |||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||
Entrez Gene | 8556 | ||||||||||||||||||
UniGene | Hs.595148 | ||||||||||||||||||
RefSeq | NP_201570 | ||||||||||||||||||
HUGO | HGNC:1718 | ||||||||||||||||||
OMIM | 603504 | ||||||||||||||||||
CCDS | CCDS771 | ||||||||||||||||||
HPRD | 04614 | ||||||||||||||||||
IMGT | |||||||||||||||||||
EMBL | AC104457 AF000367 AF064102 AF064103 AF122013 AL589990 AY623111 BC038979 BC093916 BC093918 CH471097 DQ530256 | ||||||||||||||||||
GenPept | AAB88277 AAC16659 AAC16660 AAD49217 AAH38979 AAH93916 AAH93918 AAT38107 ABF74568 CAH70068 CAH70069 CAH70070 EAW72956 EAW72958 EAW72959 | ||||||||||||||||||