InnateDB Protein
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IDBP-100536.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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EXTL2
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Protein Name
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exostoses (multiple)-like 2
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Synonyms
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EXTR2;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000359132
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InnateDB Gene
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IDBG-100534 (EXTL2)
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Protein Structure
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Function |
Glycosyltransferase required for the biosynthesis of heparan-sulfate and responsible for the alternating addition of beta-1-4-linked glucuronic acid (GlcA) and alpha-1-4-linked N- acetylglucosamine (GlcNAc) units to nascent heparan sulfate chains. {ECO:0000269PubMed:10318803}.
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Subcellular Localization |
Endoplasmic reticulum membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.Processed exostosin-like 2: Secreted. Note=A soluble form is found in the serum.
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Disease Associations |
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Tissue Specificity |
Ubiquitous.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
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Molecular Function |
Accession |
GO Term |
GO:0001888
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glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity
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GO:0016758
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transferase activity, transferring hexosyl groups
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GO:0035248
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alpha-1,4-N-acetylgalactosaminyltransferase activity
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GO:0046872
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metal ion binding
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR015338
EXTL2, alpha-1,4-N-acetylhexosaminyltransferase
IPR029044
Nucleotide-diphospho-sugar transferases
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PFAM |
PF09258
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q9UBQ6
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PhosphoSite |
PhosphoSite-Q9UBQ6
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TrEMBL |
Q8N8F1
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UniProt Splice Variant |
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Entrez Gene |
2135
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UniGene |
Hs.713048
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RefSeq |
NP_001248369
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HUGO |
HGNC:3516
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OMIM |
602411
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CCDS |
CCDS775
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HPRD |
03876
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IMGT |
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EMBL |
AB009284
AC104506
AF000416
AK096914
AK312895
CH471097
U76189
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GenPept |
AAB93669
AAC02898
BAA24081
BAC04893
BAG35742
EAW72946
EAW72947
EAW72948
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